16779-09-2Relevant academic research and scientific papers
A General Asymmetric Formal Synthesis of Aza-Baylis–Hillman Type Products under Bifunctional Catalysis
Frías, María,Carrasco, Ana Cristina,Fraile, Alberto,Alemán, José
, p. 3117 - 3121 (2018)
A new organocatalytic strategy for the synthesis of enantioenriched aza-Baylis–Hillman type products via a frustrated vinylogous reaction is presented. This process proceeds under mild conditions with good yields, completed Z/E selectivity and excellent e
Organocatalytic Asymmetric Synthesis of Benzothiazolopyrimidines via [4 + 2] Cyclization of 2-Benzothiazolimines and Aldehydes
Chen, Xue-Ping,Hou, Ke-Qiang,Zhou, Feng,Chan, Albert S. C.,Xiong, Xiao-Feng
, p. 1667 - 1675 (2021/02/03)
We report the direct asymmetric synthesis of pyrimido[2,1-b]benzothiazoles using a commercially available chiral amine catalyst. A variety of 2-benzothiazolimines and aldehydes were well tolerated under the reaction conditions and generated the corresponding products in 81-99% yields with excellent diastereoselectivities and enantioselectivities (up to >20:1 dr, 99% ee). Furthermore, the products could be easily converted to other useful chiral building blocks.
Organocatalytic asymmetric [4+2] cyclization of 2-benzothiazolimines with azlactones: Access to chiral benzothiazolopyrimidine derivatives
Ni, Qijian,Wang, Xuyang,Xu, Fangfang,Chen, Xiaoyun,Song, Xiaoxiao
supporting information, p. 3155 - 3158 (2020/03/23)
An organocatalytic asymmetric domino Mannich/cyclization reaction between 2-benzothiazolimines with azlactones has been successfully developed. With the bifunctional squaramide catalyst, this formal [4+2] cyclization occurs with good to high yields and excellent stereoselectivities (up to 99% ee, >20?:?1 dr), providing an efficient and mild access to chiral benzothiazolopyrimidines bearing adjacent tertiary and quaternary stereogenic centers.
Enantioselective synthesis of β-amino esters bearing a benzothiazole moiety via a Mannich-type reaction catalyzed by a cinchona alkaloid derivative
Li, Liang,Song, Bao-An,Bhadury, Pinaki S.,Zhang, Yu-Ping,Hu, De-Yu,Yang, Song
supporting information; experimental part, p. 4743 - 4746 (2011/10/09)
Novel β-amino esters bearing a bioactive benzothiazole moiety were obtained with high enantioselectivities (up to 95 % ee) through a Mannich-type reaction of different imines with malonate in the presence of a new chiral cinchona alkaloid thiourea catalys
