16779-15-0Relevant articles and documents
Benzothiazole Schiff-bases as potential imaging agents for β-amyloid plaques in Alzheimer's disease
Gan, Changsheng,Zhou, Lin,Zhao, Zhenzhen,Wang, Haoshu
, p. 4069 - 4074 (2013)
A series of benzothiazole Schiff-bases as potential diagnostic imaging agents targeting β-amyloid (Aβ) plaques in Alzheimer's disease (AD) were synthesized and evaluated. When in vitro binding studies using AD homogenate with [125I] 6-iodo-2-(4
Preparation and characterization of some new benzothiazole-heterocyclic derivatives
Aldujaili, Radhiya Abdul Baqi,Alhasan, Ahmed Ali Younus
, p. 2845 - 2855 (2021/05/28)
In this work new different hetero cyclic derivatives were synthesized that which including β-Lactam, teterazole and also thiazole rings.The starting material is 2-amino-6-methoxy-Benzothiazole. All these reactions follow by (TLC) and Measurement melting p
Design, synthesis, characterization and biological evaluation of 6- methoxy-2-aminobenzothioate derivatives against certain bacterial strains
Juber, Ahmood K.,Hamed, Ahmed Solaiman,Khalil, Ahmed Moussa
, p. 4131 - 4139 (2020/11/18)
The current work reports the synthesized and biological evaluation of 6-methoxy-2-amino benzothiazole (A1), which was prepared via reaction p-Ansidine with ammonium thiocyanate followed by the oxidative ring closure of the resultant thiourea with a catalytic amount of bromine, in the alkaline medium. The resulting compound(A1) underwent condensation reactions with various kinds of aldehydes to produce Hydrazones (A3ad). 6-methoxy2-hydrazinobenzothiazole (A2) was prepared through the reaction of the compound (A1) with 99.9 % hydrazine hydrate in the presence of concentrated HCl and ethylene glycol solution. After that, the compound (A2) was reacted with ethyl acetoacetate in alcohol to yield corresponding pyrazole-6- methoxybenzothiazole (A4). Moreover, the compound (A2) was reacted with 4- substituted aromatic aldehydes in absolute ethanol to create Hydrazones (A5a-d). Synthesized compounds were investigated as anti-bacterial activity against five microorganisms: (Gram-positive: Bacillus subtilis & Staphylococcus aurea). (Gramnegative: Pseudomonas aeruginous Escherichia coli and Enterobacter)
Synthesis and characterization of some 2-azetidinones and unexpected azet-2(1H)-ones
Sakarya, Handan Can,Yand?mo?lu, Merve
, p. 533 - 541 (2019/04/17)
2-Azetidinone (2b–e) and some unexpected azet-2(1H)-one derivatives (3b–f) were synthesized in two steps from the substitution of 2-aminobenzothiazole and different substituted aromatic aldehydes. Firstly, the Schiff bases were prepared via reaction of di
