16782-79-9

Upstream product

• 20469-61-8 2,3,5-trimethylanisole 
• 80-59-1 Tiglic acid 
• 541-47-9 3-Methylbutenoic acid 
• 1123-09-7 3,5-dimethyl-2-cyclohexen-1-one 
• 67333-65-7 dimethyl 4-hydroxy-2,4-dimethyl-6-oxocyclohexane-1,3-dicarboxylate 
• 1258975-16-4 dimethyl 2,4-dimethyl-6-oxocyclohex-4-ene-1,3-dicarboxylate 
• 1258975-18-6 dimethyl 1,2,4-trimethyl-6-oxocyclohex-4-ene-1,3-dicarboxylate 

Downstream Products

• 697-82-5 2,3,5-trimethylphenol 
• 70469-52-2 1,2,4,6-tetramethyl-1,3-cyclohexadiene 

Relevant academic research and scientific papers

The use of Hagemann's Esters to prepare highly functionalized phenols and benzenes

Hagemann's esters can be converted into highly functionalized phenols or arenes. The systematic functionalization of Hagemann's ester derivatives permits the preparation of tri-and tetraalkyl-substituted phenols or tetra-, penta-, and hexaalkyl-substituted benzenes. Kotnis's aromatization procedure was found to be solvent dependent, and Suzuki couplings were found to be sensitive to steric hindrance. Wittig olefination and ortho-Claisen reactions were reliable means to introduce alkyl substituents at C-4 and/or C-5 positions, respectively. The acid-promoted dehydration of tertiary alcohol 46 to produce enone 47, followed by its selective alkylation (cf. 48) is new. ARKAT USA, Inc.

Manganese(III) acetate based oxidation of substituted α′-position on cyclic α,β-unsaturated ketones

Selective oxidation of the tertiary α′-position on various 2-cyclopentenone, 2-cyclohexenone and aromatic ketone derivatives with manganese(III) acetate is described.

Dienediolates of Unsaturated Carboxylic Acids in Synthesis. Synthesis of Cyclohexenones and Polycyclic Ketones by Tandem Michael-Dieckmann Decarboxylative Annulation of Unsaturated Carboxylic Acids.

Substituted 2-cyclohexenones 4 to 7 and hexahydronaphthalenones and hexahydroindenones 13 to 18 are prepared by tandem Michael-Dieckmann addition of lithium dienediolates of acyclic and alicyclic unsaturated carboxylic acids to the lithium salts of the same or other unsaturated carboxylic acids.

Dienediolates of unsaturated carboxylic acids in synthesis. Tandem Michael-Dieckmann synthesis of substituted 2-cyclohexenones

3,5-Disubstituted 2-Cyclohexenones are prepared by tandem Michael-Diekcmann addition of lithium dienediolates of dimethylacrylic and β-methylcinnamic acids to lithium carboxylates of unsaturated carboxylic acids.