167827-87-4

Upstream product

• 180600-10-6 1,3-bis(2-naphthylmethyl)-(4α,5α,6β,7β)-hexahydro-5,6-(1-methylethylidene)bis(oxy)-2-phenoxy-4,7-bisbenzyl-1H-1,3,2-diazaphosphepine 2-oxide 
• 770-12-7 O-phenyl phosphorodichloridate 
• 153223-10-0 (2R,3S,4S,5R)-2,5-bis[N-(benzyloxycarbonyl)amino]-1,6-diphenyl-3,4-hexanediol 
• 177574-46-8 dibenzyl ((1R,1'R)-((4S,5S)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(2-phenylethane-1,1-diyl))dicarbamate 

Relevant academic research and scientific papers

Novel bicyclic phosphordiamidate HIV protease inhibitors

Several substituted (3-endo,4-endo,6-exo)-8-oxa-7-diaza-1phosphabicyclo[3.2.1]octanols were prepared and evaluated as inhibitors of HIV protease. This new bicyclic ring system is the product of an unexpected intramolecular cyclization observed upon base t

SUBSTITUTED BICYCLIC PHOSPHORAMIDES AND DERIVATIVES THEREOF

This invention relates to substituted bicyclic phosphoramides and derivatives thereof, useful as retroviral protease inhibitors and as standards and reagents in determining the ability of a potential pharmaceutical to inhibit viral replication or HIV protease, to pharmaceutical compositions comprising such compounds, and to methods of using these compounds for treating viral infection.