16791-41-6

Basic information

• Product Name: 2-BROMO-4,5-DIMETHOXYANILINE
• Synonyms: 2-BROMO-4,5-DIMETHOXYANILINE
• CAS NO: 16791-41-6
• Molecular Formula: C₈H₁₀BrNO₂
• Molecular Weight: 232.0745
• Mol File: 16791-41-6.mol
• Article Data: 8

Chemical Properties

• Melting Point: 51 °C(Solv: methanol (67-56-1))
• Boiling Point: 297.7±35.0 °C(Predicted)
• Appearance: /
• Density: 1.488±0.06 g/cm3(Predicted)
• PKA: 2.71±0.10(Predicted)
• CAS DataBase Reference: 2-BROMO-4,5-DIMETHOXYANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-4,5-DIMETHOXYANILINE(16791-41-6)
• EPA Substance Registry System: 2-BROMO-4,5-DIMETHOXYANILINE(16791-41-6)

Safety Data

• Hazardous Substances Data: 16791-41-6(Hazardous Substances Data)

Usage

General Description

2-Bromo-4,5-dimethoxyaniline is a chemical compound with the molecular formula C8H10BrNO2. It is a brominated derivative of the compound 4,5-dimethoxyaniline, which is used in the synthesis of various pharmaceuticals and organic compounds. 2-Bromo-4,5-dimethoxyaniline is used as an intermediate in the production of dyes, pigments, and other organic compounds. It is primarily used in organic synthesis and chemical research, and its properties and reactivity make it useful in a wide range of chemical processes. However, it is important to handle this chemical with care and follow safety guidelines due to its potential hazards and toxicity.

Upstream product

• 51072-66-3 1-bromo-4,5-dimethoxy-2-nitro-benzene 
• 2859-78-1 4-Bromoveratrole 
• 145352-75-6 2-acetamido-4,5-dimethoxybenzoic acid 
• 881-70-9 3',4'-dimethoxyacetanilide 
• 6315-89-5 3,4-dimethoxyaniline 
• 5349-12-2 N-(2-bromo-4,5-dimethoxyphenyl)acetamide 

Downstream Products

• 1394840-76-6 C₁₇H₁₈BrNO₅ 
• 173217-22-6 (2-Bromo-4,5-dimethoxy-phenyl)-but-3-enyl-amine 
• 29194-86-3 2-bromo-4,5-dimethoxy-N-(2-morpholin-4-yl-ethyl)-aniline 
• 5349-12-2 N-(2-bromo-4,5-dimethoxyphenyl)acetamide 
• 13794-72-4 3H-6,7-dimethoxyquinazolin-4-one 
• 13790-39-1 6,7-dimethoxy-4-chloroquinazoline 
• 146535-11-7 6,7-dimethoxy-3-phenylquinoxaline 
• 1232685-93-6 N-(2-bromo-4,5-dimethoxyphenyl)-4-oxo-2-phenyl-2,3-dihydropyridine-1-carboxamide 
• 1232685-95-8 (2S)-N-(2-bromo-4,5-dimethoxyphenyl)-2-(4-fluorophenyl)-4-oxo-2,3-dihydropyridine-1-carboxamide 

Relevant articles and documents

Cobalt in N-doped carbon matrix catalyst for chemoselective hydrogenation of nitroarenes

Anilines as important intermediates for both organic synthesis and industrial manufactory are densely substituted with a variety of functional moieties, and the transformation of nitroarenes into corresponding anilines requires catalytically selective hydrogenation catalyst. Herein, we describe a simple pyrolysis strategy to prepare cobalt catalysts in nitrogen-doped carbon matrix applied in the selective hydrogenation of nitroarenes with molecular hydrogen. The Co/NC catalysts are obtained through thermal treatment of mixed precursors of cobalt phthalocyanine and melamine. The surface-modified Co particles with Co3O4 and CoNx sites are surrounded by N-doped carbon layers according to a series of structural characterization results. These Co/NC catalysts are capable of efficiently selective hydrogenation of nitrobenzene and various substituted nitroarenes into corresponding anilines under relatively mild reaction conditions. The optimal catalytic hydrogenation performance is contributed to the fast rate of H2 dissociated activation on the CoNx active sites and the facile adsorption of the reactant substances, which is verified by the isotopic H2-D2 exchange experiments, reactant adsorption and the ORR reaction tests. Furthermore, the heterogeneous Co/NC catalyst is highly stable without the Co leaching and deactivation issues during the recycling reaction runs.

Novel Series of Dihydropyridinone P2X7 Receptor Antagonists

Identification of singleton P2X7 inhibitor 1 from HTS gave a pharmacophore that eventually turned into potential clinical candidates 17 and 19. During development, a number of issues were successfully addressed, such as metabolic stability, plasma stability, GSH adduct formation, and aniline mutagenicity. Thus, careful modification of the molecule, such as conversion of the 1,4-dihydropyridinone to the 1,2-dihydropyridinone system, proper substitution at C-5″, and in some cases addition of fluorine atoms to the aniline ring allowed for the identification of a novel class of potent P2X7 inhibitors suitable for evaluating the role of P2X7 in inflammatory, immune, neurologic, or musculoskeletal disorders.

FUSED TRIAZOLE AMINES AS P2X7 MODULATORS

Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein X, Y, R1, R2, and R3 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of dise