167944-96-9Relevant academic research and scientific papers
Stereoselective synthesis of a candoxatril intermediate via asymmetric hydrogenation
Challenger, Stephen,Derrick, Andrew,Mason, Clive P.,Silk, Terry V.
, p. 2187 - 2190 (1999)
A four step synthesis of a chiral glutarate half ester intermediate, required for the preparation of candoxatril, has been developed from t-butyl acrylate. The key steps in this route include a stereoselective synthesis of a trisubstituted alkene and its asymmetric hydrogenation with a Ru-BINAP catalyst.
