Tetrahedron Letters p. 2187 - 2190 (1999)
Update date:2022-08-03
Topics:
Challenger, Stephen
Derrick, Andrew
Mason, Clive P.
Silk, Terry V.
A four step synthesis of a chiral glutarate half ester intermediate, required for the preparation of candoxatril, has been developed from t-butyl acrylate. The key steps in this route include a stereoselective synthesis of a trisubstituted alkene and its asymmetric hydrogenation with a Ru-BINAP catalyst.
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