167992-95-2Relevant academic research and scientific papers
GASTIN AND CCK RECEPTOR LIGANDS
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, (2008/06/13)
Compounds of formula (Ia), (Ib), or (Ic), wherein A represents a group having two fused rings, or a group of formula (Id), R 1 (m) represents up to 6 substituents, K represents--O--,--S--,--CH 2--,--N(R 2)--or--N(COR 2)--, in which R 2 is H or C 1 to C 3 alkyl, W is a carbonyl, sulfonyl or sulfinyl group, provided that at least one of W and X contains carbonyl, Y and Z are as given in the description, and their pharmaceutically acceptable salts are ligands at CCK and/or gastrin receptors. STR1
Non-peptide cholecystokinin-B/gastrin receptor antagonists based on bicyclic, heteroaromatic skeletons
Kalindjian, S. Barret,Buck, Ildiko M.,Davies, Jonathan M. R.,Dunstone, David J.,Hudson, Martin L.,Low, Caroline M. R.,McDonald, Iain M.,Pether, Michael J.,Steel, Katherine I. M.,Tozer, Matthew J.,Vinter
, p. 1806 - 1815 (2007/10/03)
A series of potent and selective cholecystokinin-B/gastrin receptor antagonists based on the dibenzobicyclo[2.2.2]octane (BCO) skeleton which have recently been described were found to show species-dependent behavior when examined in rat and dog models. W
