168038-45-7

Upstream product

• 2441-07-8 benzyl (R)-2-hydroxy-3-methylbutanoate 
• 107133-12-0 methyl hydrogen <<1(R)-1-N-<(phenylmethoxy)carbonyl>amino>-2-phenylethyl>phosphonate 
• 65138-05-8 (S)-2-hydroxy-3-methylbutyric acid benzyl ester 

Downstream Products

• 167955-23-9 Benzyl (R)-2-<<<(R)-1-<(benzyloxycarbonyl)amino>-2-phenylethyl>hydroxyphosphoryl>oxy>-3-methylbutanoate 

Relevant academic research and scientific papers

(1H-Benzotriazol-1-yloxy)tris(dimethylamino)phosphonium Hexafluorophosphate- and (1H-Benzotriazol-1-yloxy)tripyrrolidinophosphonium Hexafluorophosphate-Mediated Activation of Monophosphonate Esters: Synthesis of Mixed Phosphonate Diesters, the Reactivity of the Benzotriazolyl Phosphon...

A general method for synthesizing mixed phosphonate diesters from monoesters using (1H-benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate or (1H-benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate reagents is described.The reaction proceeded through a benzotriazolyl ester as shown by comparison with other reagents such as DCC, DCC/DMAP, DCC/1-hydroxybenzotriazole, bromotris(dimethylamino)phosphonium hexafluorophosphate, or O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate and by 31P NMR analysis.This benzotriazolyl phosphonic ester intermediate was more reactive toward alcohols than toward amines, contrary to its carboxylic analogue.