2441-07-8

Basic information

• Product Name: Butanoic acid, 2-hydroxy-3-methyl-, phenylmethyl ester
• CAS NO: 2441-07-8
• Molecular Formula: C12H16O3
• Molecular Weight: 208.257
• Mol File: 2441-07-8.mol
• Article Data: 16

Chemical Properties

• CAS DataBase Reference: Butanoic acid, 2-hydroxy-3-methyl-, phenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Butanoic acid, 2-hydroxy-3-methyl-, phenylmethyl ester(2441-07-8)
• EPA Substance Registry System: Butanoic acid, 2-hydroxy-3-methyl-, phenylmethyl ester(2441-07-8)

Safety Data

• Hazardous Substances Data: 2441-07-8(Hazardous Substances Data)

Upstream product

• 17407-56-6 (R)-2-Hydroxy-3-methylbutyric acid 
• 908094-04-2 phenyldiazomethane 
• 100-51-6 benzyl alcohol 
• 4026-18-0 2-hydroxy-3-methylbutanoic acid 
• 37526-89-9 benzyl 3-methylbut-2-enoate 
• 1760-46-9 diphenylacetic anhydride 
• 117-34-0 2,2-diphenylacetic acid 
• 640-68-6 D-Val-OH 
• 100-39-0 benzyl bromide 
• 76585-78-9 phenylmethyl 3-methyl-2-oxobutanoate 

Downstream Products

• 1208982-39-1 benzyl (R)-2-(diphenylacetyloxy)-3-methylbutanoate 
• 1244784-68-6 benzyl (S)-2-(diphenylacetyloxy)-3-methylbutanoate 
• 2441-07-8 benzyl (R)-2-hydroxy-3-methylbutanoate 
• 65138-05-8 (S)-2-hydroxy-3-methylbutyric acid benzyl ester 
• 131423-64-8 benzyl (R)-4-methyl-2-(trifluoromethylsulfonyloxy)pentanoate 
• 2441-17-0 O-(2-Methoxycarbonyl-benzoyl)-(α-hydroxy-isovaleriansaeure-benzylester) 
• 889872-98-4 N-Nitroso-N-methyl-L-valyl-D-α-oxy-isovaleriansaeure-benzylester 
• 32770-00-6 Boc-Val-D-Hyv-OBzl 
• 121706-11-4 (-)-n-Hexyl indolactam V 
• 112775-95-8 7-phenetylindolactam-V 

Relevant articles and documents

Synthetic Indolactam V Analogues as Inhibitors of PAR2-Induced Calcium Mobilization in Triple-Negative Breast Cancer Cells

Human proteinase-activated receptor 2 (PAR2), a transmembrane G-protein-coupled receptor (GPCR), is an attractive target for a novel anticancer therapy, as it plays a critical role in cell migration and invasion. Selective PAR2 inhibitors therefore have potential as anti-metastatic drugs. Knowing that the natural product teleocidin A2 is able to inhibit PAR2 in tumor cells, the goal of the present study was to elaborate structure–activity relationships and to identify potent PAR2 inhibitors with lower activity against the adverse target, protein kinase C (PKC). For this purpose, an efficient gram-scale total synthesis of indolactam V (i.e., the parent structure of all teleocidins) was developed, and a library of derivatives was prepared. Some compounds were indeed found to exhibit high potency as PAR2 inhibitors at low nanomolar concentrations with improved selectivity (relative to teleocidin A2). The pseudopeptidic fragment bridging the C3 and C4 positions of the indole core proved to be essential for target binding, whereas activity and target selectivity depends on the substituents at N1 or C7. This study revealed novel derivatives that show high efficacy in PAR2 antagonism combined with increased selectivity.

COMBINATIONS OF HEPATITIS C VIRUS INHIBITORS

The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such combinations, and methods for inhibiting the function of the NS5A protein.

Surface-based ammonium ion sensor and methods of making thereof

A compound sensitive to and selective for ammonium ions over other ions. A sensor fabricated from a self assembled monolayer of said compound on gold, exhibiting sensitivity and selectivity for ammonium ions over other ions in aqueous solutions, including blood. A method of preparation of said compound and said sensor.