16807-29-7Relevant academic research and scientific papers
Aerobic Oxidative C-H Azolation of Indoles and One-Pot Synthesis of Azolyl Thioindoles by Flavin-Iodine-Coupled Organocatalysis
Tanimoto, Kazumasa,Okai, Hayaki,Oka, Marina,Ohkado, Ryoma,Iida, Hiroki
, p. 2084 - 2088 (2021/04/05)
The aerobic oxidative cross-coupling of indoles with azoles driven by flavin-iodine-coupled organocatalysis has been developed for the green synthesis of 2-(azol-1-yl)indoles. The coupled organocatalytic system enabled the one-pot three-component synthesis of 2-azolyl-3-thioindoles from indoles, azoles, and thiols in an atom-economical manner by utilizing molecular oxygen as the only sacrificial reagent.
Synthesis and evaluation of diaryl sulfides and diaryl selenide compounds for antitubulin and cytotoxic activity
Dos Santos, Edson Dos A.,Hamel, Ernest,Bai, Ruoli,Burnett, James C.,Tozatti, Camila Santos Suniga,Bogo, Danielle,Perdomo, Renata T.,Antunes, Alexandra M.M.,Marques, M. Matilde,Matos, Maria De F.C.,De Lima, Dênis P.
supporting information, p. 4669 - 4673 (2013/08/23)
We have devised a procedure for the synthesis of analogs of combretastatin A-4 (CA-4) containing sulfur and selenium atoms as spacer groups between the aromatic rings. CA-4 is well known for its potent activity as an inhibitor of tubulin polymerization, a
ARYLTHIOINDOLE TUBULIN POLYMERIZATION INHIBITORS AND METHODS OF TREATING OR PREVENTING CANCER USING SAME
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Page/Page column 42, (2010/11/08)
The present invention features arylthioindole compounds, pharmaceutical compositions of arylthioindole compounds and methods of treating a patient suffering from cancer or inflammatory, cardiac, or helminthic diseases, the method comprising administering
Arylthioindoles, potent inhibitors of tubulin polymerization
De Martino, Gabriella,La Regina, Giuseppe,Coluccia, Antonio,Edler, Michael C.,Barbera, Maria Chiara,Brancale, Andrea,Wilcox, Elizabeth,Hamel, Ernest,Artico, Marino,Silvestri, Romano
, p. 6120 - 6123 (2007/10/03)
Several arylthioindoles had excellent activity as inhibitors both of tubulin polymerization and of the growth of MCF-7 human breast carcinoma cells. Methyl 3-[(3,4,5-tri-methoxypheny)thio]-5-methoxy-1H-indole-2-carboxylate (21), the most potent derivative
