1314802-67-9Relevant academic research and scientific papers
Design and synthesis of 2-heterocyclyl-3-arylthio-1H-indoles as potent tubulin polymerization and cell growth inhibitors with improved metabolic stability
La Regina, Giuseppe,Bai, Ruoli,Rensen, Willeke,Coluccia, Antonio,Piscitelli, Francesco,Gatti, Valerio,Bolognesi, Alessio,Lavecchia, Antonio,Granata, Ilaria,Porta, Amalia,Maresca, Bruno,Soriani, Alessandra,Iannitto, Maria Luisa,Mariani, Marisa,Santoni, Angela,Brancale, Andrea,Ferlini, Cristiano,Dondio, Giulio,Varasi, Mario,Mercurio, Ciro,Hamel, Ernest,Lavia, Patrizia,Novellino, Ettore,Silvestri, Romano
experimental part, p. 8394 - 8406 (2012/02/14)
New arylthioindoles (ATIs) were obtained by replacing the 2-alkoxycarbonyl group with a bioisosteric 5-membered heterocycle nucleus. The new ATIs 5, 8, and 10 inhibited tubulin polymerization, reduced cell growth of a panel of human transformed cell lines
