168070-06-2

Upstream product

• 137393-05-6 N-((1,1-Dimethylethoxy)carbonyl)-N-methyl-L-phenylalanine phenylmethyl ester 
• 37553-65-4 Boc-N-Me-Phe-OH 
• 61-90-5 L-leucine 
• 168070-01-7 Diphenylmethyl (2S)-2-hydroxy-4-methylpentanoate 
• 168069-99-6 Diphenylmethyl (2R)-2-hydroxy-4-methylpentanoate 
• 168070-03-9 N-((1,1-Dimethylethoxy)carbonyl)-L-Leu-O-L-Leu-N(Me)-L-Phe phenylmethyl ester 
• 168070-04-0 H-L-Leu-O-L-Leu-N(Me)-L-Phe phenylmethyl ester 
• 168070-02-8 N-((1,1-Dimethylethoxy)carbonyl)-L-Leu-O-L-Leu diphenylmethyl ester 
• 168070-00-6 N-((1,1-Dimethylethoxy)carbonyl)-β-Ala-O-D-Leu diphenylmethyl ester 
• 160036-89-5 N-((1,1-Dimethylethoxy)carbonyl)-L-Leu-O-L-Leu-OH 
• 55739-21-4 N-((1,1-Dimethylethoxy)carbonyl)-β-Ala-O-D-Leu-OH 
• 13748-90-8 (S)-2-hydroxyl-3,3-dimethylbutyric acid 
• 20312-37-2 (R)-2-hydroxy-4-methylpentanoic acid 
• 328-38-1 (R)-leucine 

Downstream Products

• 128140-12-5 leualacin 
• 168069-98-5 H-β-Ala-O-D-Leu-L-Leu-O-L-Leu-N(Me)-L-Phe-OH 

Relevant academic research and scientific papers

Synthesis and evaluation of backbone/amide-modified analogs of leualacin

Leualacin (1), a cyclic depsi-pentapeptide, and its backbone/amidemodified analogs 2-4 were synthesized. Amide analogue 3 exhibited stronger vasodilatory effects. It also strongly inhibited collagen- and arachidonic acid (AA)induced platelet aggregations with IC50s of 0.6 μM and 2.0 μM, respectively.

Total synthesis of the cyclic depsipeptide leualacin

The fungal metabolite leualacin (1), a potent calcium channel antagonist, was synthesized in 15 steps from commercially available amino acids in 25% overall yield using standard solution methods. The synthesis is general and thus would accommodate the incorporation of amino acid replacements as well as the inclusion of peptide mimics and isosteres.