128140-12-5

Basic information

• Product Name: leualacin
• Synonyms: leualacin
• CAS NO: 128140-12-5
• Molecular Formula: C31H47N3O7
• Molecular Weight: 573.726
• Mol File: 128140-12-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 724.5°Cat760mmHg
• Flash Point: 392°C
• Appearance: /
• Density: 1.159g/cm³
• Vapor Pressure: 4.92E-22mmHg at 25°C
• Refractive Index: 1.54
• CAS DataBase Reference: leualacin(CAS DataBase Reference)
• NIST Chemistry Reference: leualacin(128140-12-5)
• EPA Substance Registry System: leualacin(128140-12-5)

Safety Data

• Hazardous Substances Data: 128140-12-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C31H47N3O7/c1-19(2)15-23(33)27(39)30(18-35,34(7)29(41)25(37)17-21(5)6)31(26(38)13-14-32,22-11-9-8-10-12-22)28(40)24(36)16-20(3)4/h8-12,18-20,23-25,36-37H,5,13-17,32-33H2,1-4,6-7H3/t23-,24?,25-,30-,31?/m0/s1

Upstream product

• 160036-93-1 (S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoic acid (S)-1-({(S)-1-[2-((R)-1-carboxy-3-methyl-butoxycarbonyl)-ethylcarbamoyl]-2-phenyl-ethyl}-methyl-carbamoyl)-3-methyl-butyl ester 
• 160036-90-8 (S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoic acid (S)-3-methyl-1-{methyl-[(S)-2-phenyl-1-(2,2,2-trichloro-ethoxycarbonyl)-ethyl]-carbamoyl}-butyl ester 
• 160036-91-9 (S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoic acid (S)-1-[((S)-1-carboxy-2-phenyl-ethyl)-methyl-carbamoyl]-3-methyl-butyl ester 
• 160036-88-4 (S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoic acid (S)-1-benzyloxycarbonyl-3-methyl-butyl ester 
• 55739-20-3 benzyl (2R)-2-(3-tert-butoxycarbonylaminopropionyloxy)-4-methylpentanoate 
• 37755-48-9 benzyl (2S)-2-hydroxy-4-methylpentanoate 
• 13139-15-6 N-tert-butoxycarbonyl-L-leucine 
• 137393-05-6 N-((1,1-Dimethylethoxy)carbonyl)-N-methyl-L-phenylalanine phenylmethyl ester 
• 47091-20-3 N-Methyl-L-phenylalanine phenylmethyl ester 
• 37553-65-4 Boc-N-Me-Phe-OH 
• 61-90-5 L-leucine 
• 168070-01-7 Diphenylmethyl (2S)-2-hydroxy-4-methylpentanoate 
• 168069-99-6 Diphenylmethyl (2R)-2-hydroxy-4-methylpentanoate 
• 168070-05-1 N-((1,1-Dimethylethoxy)carbonyl)-β-Ala-O-D-Leu-L-Leu-O-L-Leu-N(Me)-L-Phe phenylmethyl ester 

Relevant articles and documents

Synthesis and evaluation of backbone/amide-modified analogs of leualacin

Leualacin (1), a cyclic depsi-pentapeptide, and its backbone/amidemodified analogs 2-4 were synthesized. Amide analogue 3 exhibited stronger vasodilatory effects. It also strongly inhibited collagen- and arachidonic acid (AA)induced platelet aggregations with IC50s of 0.6 μM and 2.0 μM, respectively.

The Synthesis of Leualacin

Leualacin, a new calcium blocker isolated from Hapsidospora irregularis, has now been synthesized.