168072-85-3Relevant academic research and scientific papers
β-Glucuronyl carbamate based pro-moieties designed for prodrugs in ADEPT
Leenders,Leenders, Ruben G.G.,Gerrits,Gerrits, Kasper A. A.,Ruijtenbeek,Ruijtenbeek, Rob,Scheeren,Scheeren, Hans W.,Haisma,Haisma, Hidde J.,Boven,Boven, Epie
, p. 1701 - 1704 (1995)
A number of pro-moieties 8a-e designed for prodrug preparation have been synthesized. The pro-moieties, containing a glucuronyl carbamate group linked to a spacer possessing a terminal carboxylic acid group, have been synthesized from isocyanates 6 and an
Synthesis and biological activity of β-glucuronyl carbamate-based prodrugs of paclitaxel as potential candidates for ADEPT
De Bont, Dries B. A.,Leenders, Ruben G. G.,Haisma, Hidde J.,Van Der Meulen-Muileman, Ida,Scheeren, Hans W.
, p. 405 - 414 (2007/10/03)
The syntheses of prodrugs of paclitaxel which can be used in ADEPT in order to target paclitaxel towards tumor cells, are described. The prodrugs 1 and 2a,b consist of a spacer molecule connected via a carbamate linkage to a β-glucuronic acid. The spacer
Highly diastereoselective synthesis of anomeric β-O-glycopyranosyl carbamates from isocyanates
Leenders, Ruben G. G.,Ruytenbeek, Rob,Damen, Eric W. P.,Scheeren, Hans W.
, p. 1309 - 1312 (2007/10/03)
1-β-O-Glycopyranosyl carbamates are prepared with practically 100% β-diastereoselectivity from anomerically unprotected glycopyranosides and isocyanates. The isocyanates are prepared in situ from carboxylic acids via acyl azides.
