168133-85-5

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
N1-(2,3-DICHLOROPHENYL)-2,2-DIMETHYLPROPANAMIDE is used as a building block in the synthesis of various pharmaceuticals and agrochemicals. Its unique chemical structure allows it to be a versatile component in the development of new drugs and pesticides.
Used as a Herbicide:
N1-(2,3-DICHLOROPHENYL)-2,2-DIMETHYLPROPANAMIDE has shown potential as a herbicide. It is used to control the growth of unwanted plants and weeds in agricultural fields and other areas.
Used in Hormone Metabolism Research:
N1-(2,3-DICHLOROPHENYL)-2,2-DIMETHYLPROPANAMIDE has been studied for its effects on hormone metabolism in animals. This research can help in understanding the compound's impact on endocrine systems and its potential applications in veterinary medicine or other related fields.

InChI:InChI=1/C11H13Cl2NO/c1-11(2,3)10(15)14-8-6-4-5-7(12)9(8)13/h4-6H,1-3H3,(H,14,15)

Upstream product

• 3282-30-2 pivaloyl chloride 
• 608-27-5 2,3-dichloroaniline 

Downstream Products

• 1584714-88-4 N-(6-benzoyl-2,3-dichlorophenyl)pivalamide 
• 1584714-87-3 (2-amino-3,4-dichlorophenyl)(phenyl)methanone 

Relevant academic research and scientific papers

Carbolines, part VI. First total synthesis of Bauerine B and its demethyl analogue

Short and convergent syntheses of Bauerine B and its demethyl analogue are reported. The approach is based on a convergent methodology which involves such reactions as metalation, heteroring cross-coupling and cyclization.

Preparation method of ortho-amino trifluoroacetophenone and derivatives thereof

The invention relates to the field of organic synthesis, in particular to a preparation method of ortho-amino trifluoroacetophenone and derivatives thereof. The preparation of ortho-amino trifluoroacetophenone comprises three steps of amino protection, trifluoroacetylation and deprotection, the overall reaction condition is mild, the yield is high, and the method is suitable for large-scale production. In addition, on the basis of the preparation, substitution is carried out after amino diazotization, the ortho-amino trifluoroacetophenone derivative is further prepared, and the industrial application prospect is good.

Synthesis and structure-activity relationships of a series of substituted 2-(1H-furo[2,3-g]indazol-1-yl)ethylamine derivatives as 5-HT2C receptor agonists

A series of novel indazole derivatives were synthesized, and their structure-activity relationships examined in order to identify potent and selective 5-HT2C receptor agonists. Among these compounds, (S)-2-(7-ethyl-1H-furo[2,3-g]indazol-1-yl)-1-methylethylamine (YM348) had a good in vitro profile, that is, high agonistic activity to the human 5-HT2C receptor subtype (EC50 = 1.0 nM) and high selectivity over 5-HT2A receptors. This compound was also effective in a rat penile erection model when administered po.