168143-71-3

Basic information

• Product Name: 5-chloro-3-methyl-1-(phenylsulfonyl)-1H-indole
• Synonyms: 5-chloro-3-methyl-1-(phenylsulfonyl)-1H-indole
• CAS NO: 168143-71-3
• Molecular Weight: 305.785
• Mol File: 168143-71-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-chloro-3-methyl-1-(phenylsulfonyl)-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-chloro-3-methyl-1-(phenylsulfonyl)-1H-indole(168143-71-3)
• EPA Substance Registry System: 5-chloro-3-methyl-1-(phenylsulfonyl)-1H-indole(168143-71-3)

Safety Data

• Hazardous Substances Data: 168143-71-3(Hazardous Substances Data)

Upstream product

• 71095-42-6 5-chloro-3-methyl-1H-indole 
• 98-09-9 benzenesulfonyl chloride 
• 16382-20-0 5-chloro-3-methyl-1H-indole-2-carboxylic acid ethyl ester 
• 106-47-8 4-chloro-aniline 
• 16381-47-8 5-chloro-3-methyl-1H-indole-2-carboxylic acid 

Downstream Products

• 1394430-59-1 lithium 5-chloro-3-methyl-1-(phenylsulfonyl)-1H-indole-2-sulfinate 
• 1394430-64-8 5-chloro-N-(4-methoxybenzyl)-3-methyl-1-(phenylsulfonyl)-1H-indole-2-sulfonamide 
• 1394430-60-4 5-chloro-3-methyl-1-(phenylsulfonyl)-1H-indole-2-sulfonylchloride 
• 1394430-65-9 5-chloro-N-(4-methoxybenzyl)-3-methyl-1H-indole-2-sulfonamide 

Relevant articles and documents

Regiospecific Bromination of 3-Methylindoles with NBS and Its Application to the Concise Synthesis of Optically Active Unusual Tryptophans Present in Marine Cyclic Peptides

A regiospecific bromination of substituted 3-methylindoles at either the C(3) alkyl moiety or the C(2) position was achieved via a free radical bromination or electrophilic process, respectively. The regiospecificity of the bromination could be controlled by variation of both the substituent and the N(1) protecting group on the indole ring. In addition, enantiospecific syntheses of 5-methoxytryptophan (20) and 5-hydroxy-6-chlorotryptophan (21c) as well as concise syntheses of optically active 2-bromotryptophan ethyl esters 26a,b or their substituted derivatives in three steps from bifunctional dibromoindoles were achieved via the above regiospecific process.