168162-35-4Relevant academic research and scientific papers
Synthesis of phenoxyacetic acid derivatives as highly potent antagonists of gastrin/cholecystokinin-B receptors. II
Takeda, Yasuyuki,Kawagoe, Keiichi,Yokomizo, Aki,Yokomizo, Yoshihiro,Hosokami, Toru,Shimoto, Yoshimasa,Tabuchi, Yoshiaki,Ogihara, Yoshiyasu,Otsubo, Rira,Honda, Yuko,Yokohama, Shuichi
, p. 951 - 961 (2007/10/03)
A series of phenoxyacetanilide derivatives was synthesized and their antagonist activities for human gastrin/cholecystokinin (CCK)-B and CCK-A receptors were evaluated. Among the compounds synthesized, 2-[3-[3-[N-[2-(N- methyl-N-phenylcarbamoylmethoxy)phe
Biological activity of analogues of YM022. Novel (3-amino substituted phenyl)urea derivatives of 1,4-benzodiazepin-2-one as gastrin/cholecystokinin-B receptor antagonists
Satoh, Masato,Okamoto, Yoshinori,Koshio, Hiroyuki,Ohta, Mitsuaki,Nishida, Akito,Akuzawa, Shinobu,Miyata, Keiji,Mase, Toshiyasu,Semple, Graeme
, p. 1412 - 1414 (2007/10/03)
A series of (3-substituted phenyl)urea analogues of the potent gastrin/cholecystokinin (CCK)-B receptor antagonist YM022 has been prepared. Structure activity relationship studies of this series suggested that a number of analogues retained good in vitro potency for gastrin/CCK-B receptor. In particular, the (3-amino substituted phenyl)urea derivatives (10-12) were more potent inhibitors of pentagastrin-induced gastric acid secretion in rats than YM022 on intraduodenal (i.d.) administration.
