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132993-20-5

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132993-20-5 Usage

Description

1-(3-Nitro-phenyl)-pyrrolidine, with the molecular formula C11H12N2O2, is a pyrrolidine derivative featuring a 3-nitrophenyl group. This unique structure endows the compound with distinctive chemical properties and reactivity, making it a promising candidate for pharmaceutical and organic synthesis applications. Its potential as a building block in the synthesis of complex organic compounds and as a precursor to drug molecules with pharmacological activity highlights its versatility in research and industrial settings.

Uses

Used in Pharmaceutical Industry:
1-(3-Nitro-phenyl)-pyrrolidine is used as a building block for the synthesis of complex organic compounds and drug molecules, leveraging its unique structure and reactivity to contribute to the development of new pharmaceutical agents with potential therapeutic applications.
Used in Organic Synthesis:
1-(3-Nitro-phenyl)-pyrrolidine serves as a precursor in organic synthesis, where its nitrophenyl group imparts specific chemical and physical properties that are of interest in various research and industrial applications, enhancing the synthesis of novel organic compounds with diverse functionalities.
Used in Research Applications:
In research settings, 1-(3-Nitro-phenyl)-pyrrolidine is utilized for studying its chemical properties and reactivity, providing insights into its potential applications in the development of new materials, catalysts, or other chemical entities with specific properties tailored for various uses.

Check Digit Verification of cas no

The CAS Registry Mumber 132993-20-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,2,9,9 and 3 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 132993-20:
(8*1)+(7*3)+(6*2)+(5*9)+(4*9)+(3*3)+(2*2)+(1*0)=135
135 % 10 = 5
So 132993-20-5 is a valid CAS Registry Number.

132993-20-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(3-nitrophenyl)pyrrolidine

1.2 Other means of identification

Product number -
Other names 3-pyrrolidine-1-ylnitrobenzene

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:132993-20-5 SDS

132993-20-5Relevant articles and documents

Boron trifluoride-mediated synthesis of N-aryl-substituted pyrrolidines from tetrahydrofuran and amines

Hu, Shanshan,Huo, Yan,Wang, Zhihong

, p. 1365 - 1368 (2017)

[Figure not available: see fulltext.] Boron trifluoride-mediated transformation of tetrahydrofuran to corresponding N-aryl-substituted pyrrolidines is conducted under mild reaction conditions, providing a practical synthetic method with reasonable yields. Computational studies confirmed the reaction mechanism involving a fast Lewis acid-assisted ring-opening step, followed by the 7-membered intermediate formation and a ringclosing process as the rate-determining step.

Titanium tetrachloride-mediated synthesis of N-aryl-substituted azacycles from cyclic ethers

Sun, Zunming,Hu, Shanshan,Huo, Yan,Wang, Zhihong

, p. 4363 - 4367 (2017/01/29)

Titanium tetrachloride-mediated transformation of five- and six-membered cyclic ethers to the corresponding N-aryl-substituted azacycles is conducted in moderate to good yields under mild reaction conditions. Computational studies suggested a mechanism involving a Lewis acid-assisted ring-opening, a seven-membered metallacycle intermediate and a ring-closing process facilitated by direct participation of the metal center.

Antiprion activity of functionalized 9-aminoacridines related to quinacrine

Nguyen Thi, Hanh Thuy,Lee, Chong-Yew,Teruya, Kenta,Ong, Wei-Yi,Doh-ura, Katsumi,Go, Mei-Lin

, p. 6737 - 6746 (2008/12/21)

A library of functionalized 6-chloro-2-methoxy-(N9-substituted)acridin-9-amines structurally related to quinacrine were synthesized and evaluated for antiprion activity on four different cell models persistently infected with scrapie prion strains (ScN2a, N167, Ch2) or a human disease prion strain (F3). Most of the compounds were distinguished by the side chain attached to 9-amino of the acridine ring. These were dialkylaminoalkyl and phenyl with basic groups on the phenyl ring. The most promising compound was 6-chloro-2-methoxy-N-(4-(4-methylpiperazin-1-yl)phenyl)acridin-9-amine (15) which had submicromolar EC50 values (0.1-0.7 μM) on all cell models, was able to clear PrPSc at non-toxic concentrations of 1.2-2.5 μM, and was more active than quinacrine in terms of EC50 values. Other promising compounds were 14 (a regioisomer of 15) and 17 which had a 1-benzylpiperidin-4-yl substituent attached to the 9-amino function. Activity was strongly dependent on the presence of a substituted acridine ring, which in this library comprised 6-chloro-2-methoxy substituents on the acridine ring. The side chains of 14, 15, and 17 have not been previously associated with antiprion activity and are interesting leads for further optimization of antiprion activity.

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