168162-91-2

Upstream product

• 26214-68-6 1-methyl-pyrrole-2-carboxylic acid chloride 
• 168163-99-3 (Z)-methyl [1-(4-aminobenzoyl)-4,4-difluoro-2,3,4,5-tetrahydro-1H-1-benzo-azepine-5-ylidene]acetate 
• 183171-54-2 methyl (2Z)-(4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-ylidene)acetate 
• 183171-60-0 methyl (Z)-[4,4-difluoro-1-(4-nitrobenzoyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-5-ylidene]acetate 
• 6973-60-0 1-Methyl-2-pyrrolecarboxylic acid 
• 122-04-3 4-nitro-benzoyl chloride 

Downstream Products

• 168163-16-4 (Z)-{4,4-difluoro-1-[4-(1-methylpyrrole-2-carbonylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepin-5-ylidene}acetic acid 

Relevant academic research and scientific papers

Synthesis and biological activity of novel 4,4-difluorobenzazepine derivatives as non-peptide antagonists of the arginine vasopressin V 1A receptor

To find potent and selective antagonists of the arginine vasopressin (AVP) V1A receptor, optimization studies of compounds structurally related to (Z)-N-{4′-[(4,4-difluoro-5-carbamoylmethylidene-2,3,4,5-tetrahydro-1H- 1-benzazepin-1-yl)carbonyl

Benzazepine derivative, pharmaceutical composition thereof, and intermediate thereof

Benzazepine derivatives represented by the following general formula (I) useful as arginine vasopressin antagonists or pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and difluorobenzazepinone derivatives represented by the following general formulae (II) and (III) which are useful as production intermediates of the compound (I). STR1