168165-86-4Relevant academic research and scientific papers
Renewable functionalized pyridines derived from microbial metabolites of the alkaloid (5)-nicotine
Roduit, Jean-Paul,Wellig, Alain,Kiener, Andreas
, p. 1687 - 1702 (2007/10/03)
(S)-Nicotine, which is present in concentrations of 2-8 % in dried leaves of certain tobacco plants, was used as a starting material for the biocatalytic production of renewable functionalized pyridines. Key microbial metabolites of (5)-nicotine, such as 6-hydroxy-(5)-nicotine and 4-[(6-hydroxypyridine)-3-yl]-4-oxobutyrate were used in subsequent chemical steps for the preparation of a wide variety of 2,5-di- or 2,3,5-tri-substituted pyridines.
