168210-44-4Relevant academic research and scientific papers
Synthesis of some tricyclic heteroaromatic systems and their A1 and A2a adenosine binding activity
Colotta, V.,Cecchi, L.,Catarzi, D.,Filacchioni, G.,Martini, C.,et al.
, p. 133 - 139 (1995)
The syntheses, A%1 and A2a adenosine receptor affinities and structure-activity relationships of some 2-aryl-1,2,4-triazoloquinoxalines, 2-arylimidazoquinoxalines, 1-arylimidazoquinoxalines are reported and compared with that of a previously reported 2-phenylpyrazoloquinoxaline.The results show that some triazoloquinoxalines are potent and specific A1 adenosine receptor ligands and that the replacement of either nitrogen at position 1 or 3 of the triazoloquinoxaline moiety with a CH brought about a decrease in affinity at both adenosine receptors. adenosine receptor ligand / 1,2,4-triazoloquinoxaline / imidazoquinoxaline / imidazoquinoxaline / tricyclic heteroaromatic system
In vitro and in vivo anti-tumoral activities of imidazo[1,2-a]quinoxaline, imidazo[1,5-a]quinoxaline, and pyrazolo[1,5-a]quinoxaline derivatives
Moarbess, Georges,Deleuze-Masquefa, Carine,Bonnard, Vanessa,Gayraud-Paniagua, Stephanie,Vidal, Jean-Remi,Bressolle, Francoise,Pinguet, Frederic,Bonnet, Pierre-Antoine
, p. 6601 - 6610 (2008/12/22)
Imidazoquinoxaline and pyrazoloquinoxaline derivatives, analogues of imiquimod, were synthesized, and their in vitro cytotoxic and pharmacodynamic activities were evaluated. In vitro cytotoxicity studies were assessed against melanoma (A375, M4Be, RPMI-75
