Synthesis of some tricyclic heteroaromatic systems and their A1 and A2a adenosine binding activity

Article abstract of DOI:10.1016/0223-5234(96)88218-3

The syntheses, A%1 and A_2a adenosine receptor affinities and structure-activity relationships of some 2-aryl-1,2,4-triazolo<1,5-a>quinoxalines, 2-arylimidazo<1,2-a>quinoxalines, 1-arylimidazo<1,5-a>quinoxalines are reported and compared with that of a previously reported 2-phenylpyrazolo<1,5-a>quinoxaline.The results show that some triazoloquinoxalines are potent and specific A₁ adenosine receptor ligands and that the replacement of either nitrogen at position 1 or 3 of the triazoloquinoxaline moiety with a CH brought about a decrease in affinity at both adenosine receptors. adenosine receptor ligand / 1,2,4-triazolo<1,5-a>quinoxaline / imidazo<1,2-a>quinoxaline / imidazo<1,5-a>quinoxaline / tricyclic heteroaromatic system