168213-37-4Relevant academic research and scientific papers
In Situ Generation of Alkynylzinc and Its Subsequent Negishi Reaction in a Flow Reactor
Kandasamy, Mohanraj,Huang, Yu- Hsuan,Ganesan, Balaji,Senadi, Gopal Chandru,Lin, Wei-Yu
, p. 4349 - 4356 (2019/07/03)
A highly efficient and convenient Negishi cross-coupling reaction has been developed for the synthesis of unsymmetrical alkynes and enynes in a continuous-flow process. The reaction proceeds through an in situ generated alkynylzinc reagent by the reaction of lithium acetylide with zinc halide at room temperature followed by a cross-coupling reaction with aryl or vinyl iodides. The notable features of this work compared to the conventional benchtop method are mild reaction conditions, good to excellent yields, broad functional-group compatibility, short residence time (73 sec) and especially desilylation of TMS group with the residence time of only 10.5 sec.
Palladium(II) complex for catalyzing sonogashira coupling reactions and a method thereof
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Page/Page column 21; 22, (2017/02/09)
A palladium(II) complex which catalyzes the Sonogashira coupling reaction efficiently under aerobic condition and a method of employing the palladium(II) complex to synthesize internal alkynes. The palladium(II) complex is an effective catalyst for the co
Synthesis of functionalized alkynes via palladium-catalyzed Sonogashira reactions
Ibrahim, Mansur B.,Ali, Bassam El,Malik, Imran,Fettouhi, Mohammed
, p. 554 - 558 (2016/01/20)
A highly efficient protocol for the copper and phosphine free Sonogashira cross-coupling reactions of aryl iodides with terminal alkynes under aerobic conditions has been developed. Using 1 mol % of the palladium-bis(oxazoline) complex, Pd-BOX A, in the p
Process for preparing alkynyl-substituted aromatic and heterocyclic compounds
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Page/Page column 10, (2010/02/12)
Mono- and disubstituted aryl or heterocyclic acetylenes are produced by a process comprising reacting an aryl nitrile with an alkynylzinc compound, a bis-alkynylzinc compound, or an alkynylmagnesium compound, in the presence of a nickel/phosphine catalyst.
Selective cross-coupling of 1-ethynyl-4-iodobenzenes with activated arylacetylenes
Kovalev,Taeuchi,Asai,Ueda,Rusanov
, p. 1749 - 1754 (2007/10/03)
Conditions were found for selective cross-coupling of 1-ethynyl-2,5- dihexyl-4-iodobenzene with arylethynyl-activated arylacetylenes. The reaction is not accompanied by homo- condensation of 1-ethynyl-2,5-dihexyl-4-iodobenzene.
Alkynylation of benzonitriles via nickel catalyzed C-C bond activation
Penney, Jonathan M.,Miller, Joseph A.
, p. 4989 - 4992 (2007/10/03)
The scope of synthetically useful nickel catalyzed cross coupling reactions of benzonitriles has now been expanded to allow alkynylation. Thus, the cross coupling of benzonitriles with alkynylzinc reagents occurs readily in the presence of Ni/PMe3/s
