16825-79-9

Upstream product

• 827-98-5 dichloro(4-nitrophenyl)-λ³-iodane 
• 636-98-6 p-nitrobenzene iodide 
• 64846-47-5 4-nitrobenzene 

Downstream Products

• 64846-45-3 p-Bis-(acetoxy)-iodylnitrobenzol 
• 636-98-6 p-nitrobenzene iodide 
• 98-95-3 nitrobenzene 
• 16447-86-2 4-<18F>-fluoronitrobenzene 
• 1516-60-5 4-nitrophenyl azide 
• 305-85-1 2,6-diiodo-4-nitrophenol 
• 100-25-4 para-dinitrobenzene 
• 66959-12-4 p-Bis-(trifluoracetoxy)-iodylnitrobenzol 
• 62-23-7 4-nitro-benzoic acid 
• 64846-44-2 C₂₂H₄F₂₈INO₁₀ 
• 64846-41-9 C₁₄H₄F₁₂INO₁₀ 

Relevant academic research and scientific papers

Mild and efficient synthesis of iodylarenes using Oxone as oxidant

Mild and efficient method for the preparation of iodylarenes by oxidation of iodoarenes with Oxone in aqueous acetonitrile at room temperature is described. This new procedure allows the preparation of various iodylarenes with electron-donating or electron-withdrawing substituents in the aromatic ring including the previously unknown 1,2-diiodylbenzene.

NUCLEOPHILIC FLUORINATION OF AROMATIC COMPOUNDS

Iodylbenzene derivatives substituted with electron donating as well as electron withdrawing groups on the aromatic ring are used as precursors in aromatic nucleophilic substitution reactions. The iodyl group (IO2) is regiospecifically substituted by nucleophilic fluoride to provide the corresponding fluoroaryl derivatives. No-carrier-added [F-18] fluoride ion derived from anhydrous [F- 18]KF/Kryptofix, [F-18]CsF or a quaternary ammonium fluoride (e.g., Me4NF, Et4NF, n-Bu4NF, (PhCH2)4NF) exclusively substitutes the iodyl moiety in these derivatives and provides high specific activity F- 18 labeled fluoroaryl analogs. Iodyl derivatives of a benzothiazole analog and 6-iodyl-L-dopa derivatives have been synthesized as precursors and have been used in the preparation of no-carrier-added [F-18]fluorobenzothiazole as well as 6-[F-18]fluoro-L-dopa.

Syntheses of (diacetoxyiodo)arenes or iodylarenes from iodoarenes, with sodium periodate as the oxidant

Easy, safe, and effective novel methods for preparing either (diacetoxyiodo)-(arenes, ArI(OAc)2, or iodylarenes, ArIO2, from the corresponding iodoarenes, ArI, using sodium periodate as the oxidant are presented in this paper. In order to obtain 2- and 4-iodylbenzoic acids, the respective sodium salts of 2- and 4-iodobenzoic acids should be used as the starting substrates, because mixtures containing the corresponding iodosyl derivatives as the main products along with the intended iodyl compounds are produced from the free parent acids.

Simple anf Efficient Palladium-Catalyzed Carbonylation of Iodoxyarenes in Water under Mild Conditions

Iodoxyarenes (ArIO2) readily react with CO (1 atm) in water, in the presence of Na2 (0.1percent) and Na2CO3 at 40-50 deg C, to give the corresponding carboxylic acids, ArCOOH, in 55-89percent isolated yield.Particulary attractive features of the reaction are that, unlike most iodoarenes, ArIO2 can be carbonylated in aqueous media without any organic solvents, due to their solubility in water and high reactivity.

173.Ru-Catalyzed Oxidations with Iodosylbenzene Derivatives. Substituent Effects on Selectivity in Oxidation of Sulfides and Alcohols

Oxidation of sulfides witth PhIO/RuCl2(PPh3) leads to sulfones.Electronwithdrawing substituents in the aromatic ring of PhIO reduce the reactivity and improves selectivity of the system.Thus, with m-iodosylbenzoic acid sulfides are converted to sulfoxide.Under the same conditions aliphatic primary alcohols are transformed to aldehydes with m-iodosylbenzoic acid, while PhIO affords carboxylic acids.