168267-17-2Relevant academic research and scientific papers
F-18 radiolabeled neurokinin-1 receptor antagonists
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, (2008/06/13)
The present invention is directed to radiolabeled neurokinin-1 receptor antagonists which are useful for the labeling and diagnostic imaging of neurokinin-1 receptors in mammals.
Tetrazole NK1 receptor antagonists: The identification of an exceptionally potent orally active antiemetic compound
Armour,Chung,Congreve,Evans,Guntrip,Hubbard,Kay,Middlemiss,Mordaunt,Pegg,Vinader,Ward,Watson
, p. 1015 - 1020 (2007/10/03)
The medicinal chemistry strategy which led to the identification of GR205171, an orally active non-peptide neurokinin-1 receptor antagonist that is the most potent broad-spectrum antiemetic agent reported to date.
