168267-62-7Relevant articles and documents
Tetrazole NK1 receptor antagonists: The identification of an exceptionally potent orally active antiemetic compound
Armour,Chung,Congreve,Evans,Guntrip,Hubbard,Kay,Middlemiss,Mordaunt,Pegg,Vinader,Ward,Watson
, p. 1015 - 1020 (2007/10/03)
The medicinal chemistry strategy which led to the identification of GR205171, an orally active non-peptide neurokinin-1 receptor antagonist that is the most potent broad-spectrum antiemetic agent reported to date.