168298-09-7

Basic information

• Product Name: (3'S,4R)-3-(1'-oxobutyl-3'-phenyl)-4-phenyl-5,5-dimethyloxazolidin-2-one
• Synonyms: (3'S,4R)-3-(1'-oxobutyl-3'-phenyl)-4-phenyl-5,5-dimethyloxazolidin-2-one
• CAS NO: 168298-09-7
• Molecular Weight: 337.419
• Mol File: 168298-09-7.mol

Chemical Properties

• CAS DataBase Reference: (3'S,4R)-3-(1'-oxobutyl-3'-phenyl)-4-phenyl-5,5-dimethyloxazolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (3'S,4R)-3-(1'-oxobutyl-3'-phenyl)-4-phenyl-5,5-dimethyloxazolidin-2-one(168298-09-7)
• EPA Substance Registry System: (3'S,4R)-3-(1'-oxobutyl-3'-phenyl)-4-phenyl-5,5-dimethyloxazolidin-2-one(168298-09-7)

Safety Data

• Hazardous Substances Data: 168298-09-7(Hazardous Substances Data)

Upstream product

• 168298-07-5 (4R)-3-<2'(E)-butenoyl>-4-phenyl-5,5-dimethyloxazolidin-2-one 
• 100-58-3 phenylmagnesium bromide 

Downstream Products

• 170918-42-0 (R)-(-)-5,5-dimethyl-4-phenyl-2-oxazolidinone 
• 4593-90-2 (S)-2-phenylbutanoic acid 

Relevant articles and documents

4-Substituted-5,5-Dimethyl Oxazolidin-2-ones as Effective Chiral Auxiliaries for Enolate Alkylations and Michael Additions

4-(Methyl, phenyl, benzyl, and i-propyl)-5,5-dimethyl-oxazolidin-2-ones, readily available from α-amino acids, are shown to be effective chiral auxiliaries for stereoselective enolate alkylations and conjugate additions of attached N-acyl moieties.

The 'SuperQuat' (R)-4-phenyl-5,5-dimethyl oxazolidin-2-one as an effective chiral auxiliary for conjugate additions: Asymmetric synthesis of (-)-aplysillamide B.

(R)-4-Phenyl-5,5-dimethyl-oxazolidin-2-one, readily available from D- phenylglycine, is shown to be an effective chiral auxiliary for stereoselective conjugate additions to attached α,β-unsaturated N-acyl moieties. Its utility is demonstrated by the asymmetric synthesis of the antifungal, antibacterial (-)-Aplysillamide B.