16837-11-9

Basic information

• Product Name: 6-amino-1-(4-chlorophenyl)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one
• Synonyms: 4(1H)-pyrimidinone, 6-amino-1-(4-chlorophenyl)-2,3-dihydro-2-thioxo-
• CAS NO: 16837-11-9
• Molecular Formula: C₁₀H₈ClN₃OS
• Molecular Weight: 253.708
• Mol File: 16837-11-9.mol
• Article Data: 1

Chemical Properties

• Density: 1.56g/cm³
• Refractive Index: 1.753
• CAS DataBase Reference: 6-amino-1-(4-chlorophenyl)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-amino-1-(4-chlorophenyl)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one(16837-11-9)
• EPA Substance Registry System: 6-amino-1-(4-chlorophenyl)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one(16837-11-9)

Safety Data

• Hazardous Substances Data: 16837-11-9(Hazardous Substances Data)

Upstream product

• 105-56-6 ethyl 2-cyanoacetate 
• 3696-23-9 N-(4-chlorophenyl)thiourea 

Downstream Products

• 900447-56-5 5,6-diamino-1-(4-chlorophenyl)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one 
• 900488-86-0 6-amino-1-(4-chlorophenyl)-5-nitroso-2-thioxo-2,3-dihydropyrimidin-4(1H)-one 
• 60664-00-8 6-amino-1-(4-chloro-phenyl)-1H-pyrimidine-2,4-dione 

Relevant articles and documents

Reactions of nitriles under acidic conditions : Part IX - Synthesis of 6-amino-1-aryluracils, 6-amino-1-aryl-2-thiouracils and 6-amino-1,3-diaryl-2-thiouracils under acidic conditions

6-Amino-1-aryluracils (11a-g), 6-amino-1-aryl-2-thiouracils (12a-g), and 6-amino-1,3-diaryl-2-thiouracils (6a,b) have been synthesised through the dry hydrogen chloride gas-catalysed condensation of ethyl cyanoacetate (7) with appropriate arylureas and thioureas. 1-Aryl (12a-g) and 1,3-diaryl-2-thiouracils (6c-g) have been converted to the corresponding 1-aryl (15a-g) and novel hitherto unre-ported, 1,3-diaryluracils (5a-e) through their oxidative desulphurisation.