16837-94-8

Basic information

• Product Name: 2-Methylcyclododecane-1-one
• Synonyms: 2-Methyl-1-cyclododecanone;2-Methylcyclododecane-1-one
• CAS NO: 16837-94-8
• Molecular Formula: C₁₃H₂₄O
• Molecular Weight: 196.33
• Mol File: 16837-94-8.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Methylcyclododecane-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methylcyclododecane-1-one(16837-94-8)
• EPA Substance Registry System: 2-Methylcyclododecane-1-one(16837-94-8)

Safety Data

• Hazardous Substances Data: 16837-94-8(Hazardous Substances Data)

Upstream product

• 73367-80-3 12-bromododecanoic acid 
• 73454-01-0 1,4-Dithiaspiro<4.11>hexadecan-6-one 
• 32400-09-2 1-methylcyclododecanol 
• 67-56-1 methanol 
• 830-13-7 cyclododecanone 
• 1502-06-3 cyclodecanone 
• 3350-30-9 cyclononanone 
• 502-49-8 cycloactanone 
• 4017-60-1 ethyl 2-oxocyclododecane-1-carboxylate 
• 32399-66-9 Essigsaeure-(1-cyclododecenyl)ester 
• 62939-87-1 2-oxo-cyclododecanecarboxylic acid methyl ester 
• 74585-48-1 6-Methyl-1,4-dithia-spiro[4.11]hexadecan-6-ol 
• 73674-21-2 16,18-dimethyl-5-oxo-5,7,8,9,10,11,12,13,14,15,16,18-dodecahydro-6H-5λ⁴-thia-18-aza-benzocyclohexadecen-17-one 
• 73674-16-5 18-methyl-7,8,9,10,11,12,13,14,15,16-decahydro-6H,18H-5-thia-18-aza-benzocyclohexadecen-17-one 

Downstream Products

• 73674-43-8 2-Methyl-cyclododecanon-(2,4-dinitrophenylhydrazon) 
• 22681-52-3 1-Aethyl-2-methyl-cyclododecan 
• 820211-65-2 (Z)-3-methylcyclododecane-1,2-dione-1-oxime 
• 130409-67-5 (Z)-1-(benzoyloxy)-2-methylcyclododecene 
• 130898-26-9 N-(2-methylcyclododecylidene)benzylamine 

Relevant articles and documents

New macrolides and some sesquiterpenoid derivatives occurring in Galbanum absolute

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A Convenient Ruthenium-Catalysed α-Methylation of Carbonyl Compounds using Methanol

An efficient ruthenium catalyst is reported, for the first time, to catalyse the α-methylation of ketones and esters using methanol as a green methylating agent. The in situ generated catalyst from the complexes [RuCp*Cl2]2or [RuCp*Cl2]nwith dpePhos provided up to quantitative yields in the presence of only 20 mol% of lithium tert-butoxide (LiO-t-Bu) as a base. Regioselective mono- or multi-methylation could be effectively controlled by temperature. This catalyst system was also effective for the one-pot sequential α-alkylation–α-methylation of methyl ketones and conjugate reduction–α-methylation of α,β-unsaturated ketones to synthesise α-branched ketones. An application of the α-methylation of esters using the ruthenium catalyst was demonstrated for an alternative catalytic synthesis of Ketoprofen. (Figure presented.).

Enzyme-mediated enantioface-differentiating hydrolysis of α-substituted cycloalkanone enol esters

A new type of enzymatic hydrolysis, enantioface-differentiating hydrolysis of enol esters, is disclosed. As a result of screening, Pichia miso IAM 4682, a type of yeast, was selected as the best strain to perform the enantioselective hydrolysis of enol esters to give α-chiral ketones. For example, incubation of 1-acetoxy-2-methylcyclohexene (4a) with P. miso afforded (S)-2-methylcyclohexanone (5) in high optical yield. This enzymatic hydrolysis is applicable to various α-substituted cycloalkanone enol esters, and thereby chiral six-, eight-, ten-, and twelve-membered-ring ketones of 70-96% enantiomeric excess (ee) are easily prepared.