16840-84-9Relevant articles and documents
COMPOUNDS USEFUL IN HIV THERAPY
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Page/Page column 106-107; 135-136, (2021/10/02)
The invention relates to compounds of Formula (I), salts thereof, pharmaceutical compositions thereof, as well as methods of treating or preventing HIV in subjects.
Synthesis and antimicrobial activity of symmetrical two-tailed dendritic tricarboxylato amphiphiles
Sugandhi, Eko W.,Falkinham III, Joseph O.,Gandour, Richard D.
, p. 3842 - 3853 (2008/02/09)
Two series of water-soluble, symmetrical two-tailed homologous dendritic amphiphiles-R2NCONHC((CH2)2COOH)3, 2(n,n), and R2CHNHCONHC((CH2)2COOH)3, 3(n,n), where R = n-CnH2n+1-were synthesized and compared to R″NHCONHC((CH2)2COOH)3, 1(n), R″ = n-CnH2n+1, to determine whether antimicrobial activity was influenced by total or individual alkyl chain lengths, and whether antimicrobial activity depends on hydrophobicity or tail topology (one or two). In a broad screen of 11 microorganisms, 2(n,n) and 3(n,n) generally displayed higher minimal inhibitory concentrations (MICs) than 1(n) against growth as measured by broth microdilution assays. Chain-length specificity was observed against Candida albicans as 1(16), 2(8,8), and 3(8,8) showed the lowest MIC in their respective series. The one case where two-tailed compounds displayed the lowest MICs-3(10,10), 15 μM; 3(11,11), 7.2 μM; and 3(12,12), 6.9 μM-was against Cryptococcus neoformans.
TENSION SUPERFICIELLE ET MICELLISATION D'ALKYL SULFONATES DE SODIUM A DEUX CHAINES EGALES
Granet, Robert,Piekarski, Salomon
, p. 131 - 136 (2007/10/02)
Five new symetrical double tailed alkyl sodium sulfonates R(R)CH-SO3Na, each chain varying from 7 to 11 carbon atoms, have been synthesized and purified.Their solubilities in distillled water have been determined between 0 and 80 deg C.From measurement of surface tension, the curve γ = f(log C) permits the determination of the CMC and the surface excess.A linear plot of log(CMC) versus the total number of carbons have been established.The area per molecule near the CMC is the same for all the terms of the serie.The surface tension above the CMC decreases from 25.7 to 21.4 mN/m when the alkyl chain grows, from R = C7H16 to R = C11H23 at 60 deg C.In the presence of added NaCl, the area per molecule decreases to 55 +/- 5 Angstroem and the evolution of the CMC values versus salinity gives an estimation of the ionization degree of the micelles.
Synthese et proprietes superficielles d'alkylsulfonates de sodium secondaires et symetriques a l'interface eau-air et eau-alcanes
Dusart, Odile
, p. 491 - 496 (2007/10/02)
New double-tail surfactants have been synthetized and purified: (CH3(CH2)5)2CHSO3Na (I) et (CH3(CH2)8)2CHSO3Na (II). Air-water and alkanes-water interfacial tensions are determined at 45 deg C.The influence of the salinity is considered. The composition of the adsorbed monolayer near cmc is determined using the GIBBS equation.In pure water the area for both I and II is (110 +/- 5) Angstroem2/molecule.In 0.5 M NaCl the area is (48 +/- 5) Angstroem2/molecule.The cmc values in pure water are found to be 9E-3 mol/l and 7E-5 mol/l respectively.The dependence of the cmc on the NaCl concentration gives an estimate of the degree of ionization of the micelles. Low interfacial tensions were observed in the presence of NaCl against n-heptane for (I) and n-decane for (II).