16841-53-5 Usage
Uses
Used in Pharmaceutical Industry:
1-(ethenylsulfonyl)butane is used as a reagent for the synthesis of various pharmaceutical compounds. Its nucleophilic nature allows it to participate in key chemical reactions, such as nucleophilic addition and substitution, which are essential in creating a wide range of medicinal agents.
Used in Agrochemical Industry:
Similarly, in the agrochemical sector, 1-(ethenylsulfonyl)butane serves as a reagent in the production of different agrochemicals. Its ability to engage in nucleophilic reactions contributes to the development of compounds used in agricultural applications to protect crops and enhance yields.
Used in Polymer Science:
1-(ethenylsulfonyl)butane is also utilized as a cross-linking agent in polymerization processes. Its reactive vinyl sulfonyl group aids in forming covalent bonds between polymer chains, thereby influencing the physical properties of the resulting polymers, such as their strength and stability.
Safety Precautions:
Given the reactive nature of 1-(ethenylsulfonyl)butane and its potential health hazards, it is crucial to follow proper safety measures when handling and using this chemical compound. This includes wearing appropriate personal protective equipment, working in well-ventilated areas, and adhering to established safety protocols to minimize risks.
Check Digit Verification of cas no
The CAS Registry Mumber 16841-53-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,6,8,4 and 1 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 16841-53:
(7*1)+(6*6)+(5*8)+(4*4)+(3*1)+(2*5)+(1*3)=115
115 % 10 = 5
So 16841-53-5 is a valid CAS Registry Number.
16841-53-5Relevant academic research and scientific papers
Alkyl sulfonyl derivatized PAMAM-G2 dendrimers as nonviral gene delivery vectors with improved transfection efficiencies
Morales-Sanfrutos, Julia,Megia-Fernandez, Alicia,Hernandez-Mateo, Fernando,Giron-Gonzalez, Ma Dolores,Salto-Gonzalez, Rafael,Santoyo-Gonzalez, Francisco
experimental part, p. 851 - 864 (2011/03/22)
Amphiphilic dendrimer-based gene delivery vectors bearing peripheral alkyl sulfonyl hydrophobic tails were constructed using low-generation PAMAM-G2 as the core and functionalized by means of the aza-Michael type addition of its primary amino groups to vinylsulfone derivatives as an efficient tool for surface engineering. While the unmodified PAMAM-G2 was unable to efficiently transfect eukaryotic cells, functionalized PAMAM-G2 dendrimers were able to bind DNA at low N/P ratios, protect DNA from digestion with DNase I and showed high transfection efficiencies and low cytotoxicity. Dendrimers with a C18 alkyl chain produced transfection efficiencies up to 3.1 fold higher than LipofectAMINE 2000 in CHO-k1 cells. The dendriplexes based in functionalized PAMAM-G2 also showed the ability to retain their transfection properties in the presence of serum and the ability to transfect different eukaryotic cell lines such as Neuro-2A and RAW 264.7. Taking advantage of the vinylsulfone chemistry, fluorescent PAMAM-G2 derivatives of these vectors were prepared as molecular probes to determine cellular uptake and internalization through a clathrin-independent mechanism.
