168553-76-2

Upstream product

• 6346-09-4 4-aminobutyrylaldehyde diethylacetal 
• 1148-11-4 N-Benzyloxycarbonyl-L-proline 

Downstream Products

• 222610-98-2 diphenyl 1-(Z-(S)-prolyl)pyrrolidine-2(R,S)-phosphonate 
• 222610-96-0 2,2'-biphenylyl 1-(benzyloxycarbonyl-(S)-prolyl)pyrrolidine-2(R,S)-phosphonate 
• 222610-64-2 bis(4-acetoxyphenyl) 1-(benzyloxycarbonyl-(S)-prolyl)pyrrolidine-2(R,S)-phosphonate 
• 222610-65-3 bis(3-acetamidophenyl) 1-(benzyloxycarbonyl-(S)-prolyl)pyrrolidine-2(R,S)-phosphonate 
• 222610-66-4 bis(4-acetamidophenyl) 1-(benzyloxycarbonyl-(S)-prolyl)pyrrolidine-2(R,S)-phosphonate 
• 222610-67-5 bis<4-(methylsulfonylamino)phenyl> 1-(benzyloxycarbonyl-(S)-prolyl)pyrrolidine-2(R,S)-phosphonate 

Relevant academic research and scientific papers

Serine proteases, their activity and their synthetic inhibitors

PCT No. PCT/EP95/02255 Sec. 371 Date Feb. 19, 1997 Sec. 102(e) Date Feb. 19, 1997 PCT Filed Jun. 9, 1995 PCT Pub. No. WO95/34538 PCT Pub. Date Dec. 21, 1995The present invention relates to new compounds of the general formula: Z-Xaa-Y', in which Xaa is an amino acid, Z is a protecting group and Y' is one of various types of ring structures. The new compounds have a modulating activity on serine proteases. The invention further relates to the use of the compounds in therapy and diagnosis and to a method of purifying the serine protease DPPIV.

A New Synthetic Mehtod for Proline Diphenyl Phosphonates

The diphenyl ester of the phosphonic acid analogue of proline and related dipeptides were prepared by a reaction of the corresponding N-substituted 4-aminobutyraldehyde and triphenyl phosphite.Diastereoisomers were separated and their configuration determined by X-ray crystallography.