222610-98-2

Upstream product

• 101-02-0 triphenyl phosphite 
• 168553-76-2 4-(Z-(S)-prolyl)aminobutyraldehyde diethyl acetal 

Downstream Products

• 222610-34-6 [1-((S)-Pyrrolidine-2-carbonyl)-pyrrolidin-2-yl]-phosphonic acid diphenyl ester 
• 222610-61-9 diphenyl 1-(trityl-(S)-prolyl)pyrrolidine-2(R)-phosphonate 

Relevant academic research and scientific papers

A New Synthetic Mehtod for Proline Diphenyl Phosphonates

The diphenyl ester of the phosphonic acid analogue of proline and related dipeptides were prepared by a reaction of the corresponding N-substituted 4-aminobutyraldehyde and triphenyl phosphite.Diastereoisomers were separated and their configuration determined by X-ray crystallography.

Serine proteases, their activity and their synthetic inhibitors

PCT No. PCT/EP95/02255 Sec. 371 Date Feb. 19, 1997 Sec. 102(e) Date Feb. 19, 1997 PCT Filed Jun. 9, 1995 PCT Pub. No. WO95/34538 PCT Pub. Date Dec. 21, 1995The present invention relates to new compounds of the general formula: Z-Xaa-Y', in which Xaa is an amino acid, Z is a protecting group and Y' is one of various types of ring structures. The new compounds have a modulating activity on serine proteases. The invention further relates to the use of the compounds in therapy and diagnosis and to a method of purifying the serine protease DPPIV.