16859-12-4Relevant academic research and scientific papers
Synthesis of N,N′-carbonyl-bis-amino acids and N,N′-carbonyl-bis-peptides
Izdebski,Pawlak
, p. 1066 - 1074 (2007/10/03)
A new method for the preparation of N,N′-carbonyl-bis-amino acid esters by reaction of bis(4-nitrophenyl)carbonate with amino acid esters is described. When the carbonate reacts with two equivalents of a peptide ester, N,N′-carbonyl-bis(peptide ester) is obtained but, a hydantoin derivative is formed as a side product. The hydantoin derivative is a major product, when equimolar amounts are allowed to react. Usefulness of this method for preparation of larger N,N′carbonyl-bis-peptides is demonstrated by the synthesis of the respective product from C-terminal hexapeptide of Substance P linked to the Merrifield resin.
