16860-57-4

Usage

Class

Organic compounds

Subclass

Phenylpyrazoles

Specific family

Diphenylpyrazole

Structure

Pyrazole ring attached to two phenyl groups

Chlorophenyl group location

5-position (3-chlorophenyl)

Potential hazards

Toxic (handle with caution)

Uses

Pharmaceutical and research purposes

Studied in

Scientific fields for properties and potential applications

Upstream product

• 57488-03-6 1,3-diphenyl-5-(3-chlorophenyl)-2-pyrazoline 
• 100-63-0 phenylhydrazine 

Relevant academic research and scientific papers

Photooxidation of 3,5-diaryl-1-phenyl-2-pyrazolines: Experimental and computational studies

Photooxidation of various 2-pyrazolines is studied experimentally and computationally. Experimental results show that the electron-donating/withdrawing substituents increases/decreases the rate of this photoreaction. The proposed light-induced electron-tr

Silica-supported 1,3-dichloro-5,5-dimethylhydantoin (DCH) as a useful reagent for microwave-assisted aromatization of 1,3,5-trisubstituted pyrazolines under solvent-free conditions

1,3,5-Trisubstituted pyrazolines are rapidly and conveniently oxidized to their corresponding pyrazoles by 1,3-dichloro-5,5-dimethylhydantoin (DCH) in solution and solvent-free conditions under microwave irradiation. The presence of silica gel as a suppor

Aromatization of 1,3,5-trisubstituted of 4,5-dihydro-1H-pyrazoles by in-situ generation of I+ from hydrogen Peroxide/Acids/iodide potassium or sodium systems

A simple, green and cost-effective protocol was used for the aromatization of 1,3,5-trisubstituted-2-pyrazolines to the corresponding pyrazoles by in situ generation of iodine (I+) from H2O2/AcOH or SSA or oxalic acid /KI

A convenient and efficient protocol for the synthesis of 5-aryl-1,3-diphenylpyrazole catalyzed by hydrochloric acid under ultrasound irradiation

The synthesis of 5-aryl-1,3-diphenylpyrazole via the reactions of 3-aryl-2,3-epoxy-1-phenyl-1-propanone with phenylhydrazine was carried out in 69-99% yields at room temperature under ultrasound irradiation. This method provides several advantages such as

An efficient oxidation of 2-pyrazolines and isoxazolines by bis-bromine-1,4-diazabicyclo[2.2.2]octane complex (DABCO-Br2)

An efficient and simple procedure has been developed for the oxidation of 1,3,5-trisubstituted 4,5-dihydro-1H-pyrazoles and -isoxazoles to their corresponding aromatic derivatives promoted by bis-bromine-1,4-diazabicyclo[2.2. 2]octane complex (DABCO-Brsu

Solvent-free synthesis of 1, 3-diphenyl-5-arylpyrazole derivatives

The synthesis of 1, 3-diphenyl-5-arylpyrazoles via the reactions of 2, 3-epoxy-1-phenyl-3-aryl-1-propanones with phenylhydrazine was carried out in 48-84% yields at 230 °C under solvent-free condition within 1.5 h. This method provides several advantages

Oxidative aromatization of 1,3,5-trisubstituted 4,5-dihydro-1H-pyrazoles efficiently by tetrabromine-1,3,5,7-tetrazatricyclo[3.3.1.13,7]decane complex, Br4-TATCD, as a novel reagent both under microwave irradiation and at room temper

Oxidation of 1,3,5-trisubstituted 4,5-dihydro-1H-pyrazoles to the corresponding pyrazoles has been achieved by utilizing tetrabromine-1,3,5,7-tetrazatricyclo[3.3.1.13,7]decane complex, Br4-TATCD, in glacial acetic acid under microwav

Silica sulfuric acid-activated poly-1,3-dichloro-5methyl-5-(4'-vinylphenyl)hydantoin (PDCVH) as an effective reagent for oxidation of 1,3,5-trisubstituted 2-pyrazolines both under microwave irradiation and thermal conditions

Oxidation of 1,3,5-trisubstituted 4,5-dihydro-1H-pyrazoles to the corresponding pyrazoles has been achieved by utilizing silica sulfuric acidactivated poly-1,3-dichloro-5-methyl-5(4'-vinylphenyl)hydantoin in EtOH under both microwave irradiation and conve

Microwave-promoted oxidation of 1,3,5-trisubstituted 4,5-dihydro-1H- pyrazoles by in-situ generation of NO+ and NO2+ respectively from sodium nitrite and sodium nitrate in acetic acid

(Chemical Equation Presented) Microwave-assisted aromatization of 1,3,5-trisubstituted 4,5-dihydro-1H-pyrazoles by in-situ generation of NO + and NO2+ respectively from sodium nitrite and sodium nitrate in acetic acid has

Microwave-assisted aromatization of 1,3,5-trisubstituted 2-pyrazolines by Bi(NO3)3 · 5H2O, as a novel and convenient oxidizing agent

Bismuth(III) nitrate pentahydrate, Bi(NO3)3 · 5H2O, has been used as a mild, efficient, and inexpensive oxidant for the oxidative aromatization of several 1,3,5-trisubstituted 2-pyrazolines to pyrazoles in acetic acid unde