16867-55-3

Upstream product

• 1072-98-6 5-chloro-2-pyridylamine 
• 87-13-8 diethyl 2-ethoxymethylenemalonate 
• 16867-57-5 diethyl (5-chloro-2-pyridylamino)methylene malonate 

Downstream Products

• 1609379-99-8 Ethyl 7-(4-methoxyphenyl)-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylate 
• 1609380-00-8 7-(4-methoxyphenyl)-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acid 
• 1609380-01-9 N-(3-fluorobenzyl)-7-(4-methoxyphenyl)-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxamide 
• 1609380-03-1 N-(4-trifluoromethylbenzyl)-7-(4-methoxyphenyl)-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxamide 
• 1609380-04-2 N-(tetrahydrofuran-2-ylmethyl)-7-(4-methoxyphenyl)-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxamide 
• 1609380-02-0 N-(3-trifluoromethylbenzyl)-7-(4-methoxyphenyl)-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxamide 

Relevant academic research and scientific papers

Pyrido[1,2-a]pyrimidin-4-ones as antiplasmodial falcipain-2 inhibitors

Plasmodium falciparum cysteine protease falcipain-2 (FP-2) is a promising target for antimalarial chemotherapy and inhibition of this protease affects the growth of parasite adversely. A series of pyrido[1,2-a]pyrimidin-4-ones were synthesized and evaluat