16867-56-4

Usage

Uses

Used in Pharmaceutical Industry:
Ethyl 7-bromo-4-oxo-pyrido[1,2-a]pyrimidine-3-carboxylate is used as a building block for the synthesis of various biologically active molecules, such as potential drug candidates. Its unique structure and properties contribute to the development of new compounds with potential pharmacological applications.
Used in Chemical Industry:
In the chemical industry, Ethyl 7-bromo-4-oxo-pyrido[1,2-a]pyrimidine-3-carboxylate serves as an intermediate for the development of new compounds with potential applications in various fields, including agrochemicals.
Used as a Research Tool:
Ethyl 7-bromo-4-oxo-pyrido[1,2-a]pyrimidine-3-carboxylate is utilized as a research tool in drug discovery and development processes, aiding in the exploration of its potential medical and agricultural uses.

Upstream product

• 87-13-8 diethyl 2-ethoxymethylenemalonate 
• 1072-97-5 5-bromo-2-pyridylamine 
• 16867-58-6 diethyl 2-[[(5-bromo-2-pyridyl)amino]methylene]propanedioate 
• 40131-09-7 diethyl methoxymethylenemalonate 

Relevant academic research and scientific papers

Investigating structural aspects of Pyridopyrimidinone derivatives, an important precursor in medicinal chemistry

Pyridopyrimidinones are class of heterocyclic compounds which serves as important precursors in organic transformation and medicinal chemistry. In the current work three derivatives of pyrido[1,2-a]pyrimidine-3-carboxylates (1, 2 and 3) has been synthesized and characterized by NMR. The crystal structure of compound 1 (C12H12N2O3.HCl) and 2 (2(C12H12N2O3)) were solved in monoclinic system with P21/c space group and 3 (C11H9BrN2O3) shows concomitant polymorphism and solved in orthorhombic system with Pna21 and Pca21. The weak C—H?O and C—H…N intermolecular interactions play significant role in crystal packing of 4-Oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylates. Replacement of methyl group in compound 1 with Bromine atom resulted 3 with increased π…π stacking interactions. The unexpected concomitant polymorphic forms of compounds 3 with details of the crystal structures and supramolecular features are presented. In addition, Hirshfeld surface and 2D fingerprint plots were performed to understand the various intermolecular non-covalent interactions in pyrido[1,2-a]pyrimidine-3-carboxylates.

OXOPYRIDO[1,2-A]PYRIMIDINE COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF BACTERIAL INFECTION

The present invention relates to novel compounds of formula (I), wherein R1 to R7 are as described herein, and their pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.

Pyrido[1,2-a]pyrimidone analogs as PI3K inhibitors

The present invention discloses a class of pyrido[1,2-a]pyrimidone analogs as PI3K inhibitors, and particularly relates to a compound represented by a formula (I) or a pharmaceutically acceptable salt thereof. The formula (I) is defined in the specification.