168699-01-2Relevant articles and documents
Selective protection of the primary amine functions of linear tetraamines using the trityl group
Krakowiak, Krzysztof E.,Bradshaw, Jerald S.
, p. 3451 - 3459 (1998)
Treatment of linear tetraamines 3,6-diaza-1,8-octanediamine (1); 4,7- diaza-1,10-decanediamine (2); and 4,9-diaza-1,12-dodecanediamine (spermine) (3) with equimolar amounts of trityl chloride allowed preparation of the α,ω-bistrityl-protected tetraamines 4, 6 and 8 in good to excellent yields. A 2:1 ratio of trityl chloride to tetraamine gave a tritrityl-substituted by- product. An internal N,N'-ditrityl-substituted tetraamine, 5,8-ditrityl- 1,5,8,12-tetraazadodecane (10), was also prepared as a further proof of the structures of the α,ω-ditrityl-substituted tetraamines.
Simple total syntheses of N-substituted polyamine derivatives using N-tritylamino acids
Mamos, Petros,Karigiannis, Georgios,Athanassopoulos, Costas,Bichta, Sofia,Kalpaxis, Dimitrios,Papaioannou, Dionissios,Sindona, Giovanni
, p. 5187 - 5190 (2007/10/02)
A general methodology for the total synthesis of N-alkyl- and acylpolyamine derivatives is described which is based on the coupling of suitable N-tritylamino acids with amines followed by lithium aluminium hydride reduction of the thus obtained amides.
