213403-58-8Relevant academic research and scientific papers
Xylylated dimers of putrescine and polyamines: Influence of the polyamine backbone on spermidine transport inhibition
Covassin, Laurence,Desjardins, Michel,Soulet, Denis,Charest-Gaudreault, Rene,Audette, Marie,Poulin, Richard
, p. 3267 - 3271 (2003)
Dimeric norspermidine and spermidine derivatives are strong competitive inhibitors of polyamine transport. A xylyl tether was used for the dimerization of various triamines and spermine via a secondary amino group, and of putrescine via an ether or an amino group. Dimerization of putrescine moieties potentiates their ability to compete against spermidine transport to a much greater extent than for triamine dimers.
Simple syntheses of the polyamine alkaloid tenuilobine and analogues using selectively N-tritylated polyamines and dicarboxylic acids as bridging elements
Vassis, Stratos,Govaris, Ioannis,Voyagi, Katerina,Mamos, Petros,Papaioannou, Dionissios
, p. 2597 - 2600 (2007/10/03)
Selectively N-tritylated spermidine and spermine derivatives and the monophenacyl ester of 1,16-hexadecanedioic acid (Hda) were used to obtain the polyamine alkaloid tenuilobine and its fully reduced analogue. Other symmetric or side-chain-shortened tenui
Selective protection of the primary amine functions of linear tetraamines using the trityl group
Krakowiak, Krzysztof E.,Bradshaw, Jerald S.
, p. 3451 - 3459 (2007/10/03)
Treatment of linear tetraamines 3,6-diaza-1,8-octanediamine (1); 4,7- diaza-1,10-decanediamine (2); and 4,9-diaza-1,12-dodecanediamine (spermine) (3) with equimolar amounts of trityl chloride allowed preparation of the α,ω-bistrityl-protected tetraamines 4, 6 and 8 in good to excellent yields. A 2:1 ratio of trityl chloride to tetraamine gave a tritrityl-substituted by- product. An internal N,N'-ditrityl-substituted tetraamine, 5,8-ditrityl- 1,5,8,12-tetraazadodecane (10), was also prepared as a further proof of the structures of the α,ω-ditrityl-substituted tetraamines.
