154464-26-3

Basic information

• Product Name: 3-(CYCLOPENTYLOXY)-4-METHOXYANILINE
• Synonyms: 3-CYCLOPENTYLOXY-4-METHOXY-PHENYLAMINE;3-(CYCLOPENTYLOXY)-4-METHOXYANILINE;BUTTPARK 95\04-16
• CAS NO: 154464-26-3
• Molecular Formula: C₁₂H₁₇NO₂
• Molecular Weight: 207.27
• Mol File: 154464-26-3.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 342.6°Cat760mmHg
• Flash Point: 176.5°C
• Appearance: /
• Density: 1.123g/cm³
• Vapor Pressure: 7.44E-05mmHg at 25°C
• Refractive Index: 1.567
• Storage Temp.: 2-8°C
• PKA: 4.44±0.11(Predicted)
• CAS DataBase Reference: 3-(CYCLOPENTYLOXY)-4-METHOXYANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(CYCLOPENTYLOXY)-4-METHOXYANILINE(154464-26-3)
• EPA Substance Registry System: 3-(CYCLOPENTYLOXY)-4-METHOXYANILINE(154464-26-3)

Safety Data

• Hazard Codes: Xi:Irritant
• Statements: R36/37/38:Irritating to eyes, respiratory system and skin.
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S37/39:Wear suitable g
• Hazardous Substances Data: 154464-26-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H17NO2/c1-14-11-7-6-9(13)8-12(11)15-10-4-2-3-5-10/h6-8,10H,2-5,13H2,1H3

Upstream product

• 636-93-1 5-nitroguaiacol 
• 70571-31-2 1-benzylpiperidine-2,4-dione 
• 1197924-28-9 3-cyclopentyloxy-4-methoxyacetanilide 
• 3251-57-8 N-(3-hydroxy-4-methoxyphenyl)acetamide 
• 51-66-1 4-methoxyacetanilide 
• 53606-42-1 N-(3-Acetoxy-4-methoxyphenyl)acetamide 
• 504-02-9 1,3-cylohexanedione 
• 7440-44-0 pyrographite 
• 154464-25-2 1-cyclopentyloxy-2-methoxy-5-nitrobenzene 
• 137-43-9 Cyclopentyl bromide 
• 1687-53-2 5-amino-2-methoxyphenol 

Downstream Products

• 460080-79-9 3-cyclopentyloxy-4-methoxydiphenylamine 
• 159782-49-7 N-(3,5-dichloropyrid-4-yl)-N'-(3-cyclopentyloxy-4-methoxyphenyl)urea 
• 133332-20-4 (E)-methyl-3-<3-(cyclopenyloxy)-4-methoxyphenyl>prop-2-enoate 
• 1021867-92-4 methyl 3-(3-cyclopentyloxy-4-methoxyphenyl)-4-nitrobutanoate 
• 61413-54-5 Rolipram 
• 1185159-70-9 C₆₅H₉₉Cl₂N₃O₁₆S 
• 1185158-93-3 C₆₁H₉₁Cl₂N₃O₁₆S 
• 1185160-22-8 C₆₂H₉₃Cl₂N₃O₁₆S 
• 1185159-67-4 C₆₃H₉₇Cl₂N₃O₁₅S 
• 1176169-64-4 C₆₀H₉₁Cl₂N₃O₁₅S 
• 1185160-27-3 C₅₉H₈₉Cl₂N₃O₁₅S 
• 1185160-89-7 C₆₁H₉₅N₃O₁₅S 
• 1185160-69-3 3-cyclopentyloxy-4-methoxy-phenylamine 
• 1185160-71-7 C₂₀H₂₄Cl₂N₂O₂S 

Relevant articles and documents

Transition metal free intramolecular selective oxidative C(sp3)-N coupling: Synthesis of N-aryl-isoindolinones from 2-alkylbenzamides

A synthetic method has been developed for the preparation of biologically important isoindolinones including indoprofen and DWP205190 drugs from 2-alkylbenzamide substrates by transition metal-free intramolecular selective oxidative coupling of C(sp3)-H and N-H bonds utilizing iodine, potassium carbonate and di-tert-butyl peroxide in acetonitrile at 110-140 °C.

From paracetamol to rolipram and derivatives: Application of deacetylation-diazotation sequences and palladium-catalyzed matsuda-heck reaction

A six-step synthesis of the antidepressant rolipram from the popular analgetic 4-acetamidophenol (paracetamol) is described. The steps include oxidative functionalization of the aromatic core, diazonium salt formation via deacetylation-diazotation, Matsuda-Heck reaction, conjugate addition of nitromethane, and hydrogenative cyclization. Georg Thieme Verlag Stuttgart · New York.

PHOSPHODIESTERASE 4 INHIBITORS, INCLUDING N-SUBSTITUTED ANILINE AND DIPHENYLAMINE ANALOGS

PDE4 inhibition is achieved by novel compounds, e.g., N-substituted aniline and diphenylamine analogs. The compounds of the present invention are of Formula (I): wherein R1, R2 R 3 and R4 are as defined herein.