168702-54-3

Upstream product

• 100-39-0 benzyl bromide 
• 97-51-8 5-Nitrosalicylaldehyde 
• 204130-60-9 2-(benzyloxy)-5-nitrobenzaldehyde 
• 39224-61-8 2-hydroxy-5-nitrobenzyl alcohol 

Downstream Products

• 518058-81-6 [5-amino-2-(benzyloxy)phenyl]methanol 
• 1026486-04-3 (S)-2-(Benzhydrylidene-amino)-3-(2-benzyloxy-5-nitro-phenyl)-1-((1R,5S,7S)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-propan-1-one 
• 1026414-80-1 (S)-2-[(S)-3-(2-Benzyloxy-5-nitro-phenyl)-2-tert-butoxycarbonylamino-propionylamino]-propionic acid methyl ester 
• 168702-60-1 2-(Benzhydrylidene-amino)-3-(2-benzyloxy-5-nitro-phenyl)-propionic acid ethyl ester 
• 168702-68-9 Ac-L-o-Nip(Bn)-Ala-OMe 
• 168702-62-3 Boc-o-Nip(Bn)-OEt 
• 1027951-56-9 (S)-2-[(S)-2-Amino-3-(2-benzyloxy-5-nitro-phenyl)-propionylamino]-propionic acid methyl ester 
• 168702-64-5 Boc-L-o-Nip(Bn) 
• 1810074-88-4 L-o-Tyr hydrochloride 
• 1027892-43-8 (S)-2-[(S)-2-Acetylamino-3-(5-amino-2-hydroxy-phenyl)-propionylamino]-propionic acid methyl ester 
• 1027149-76-3 (S)-2-Amino-3-(2-benzyloxy-5-nitro-phenyl)-propionic acid 
• 168702-56-5 2-(Benzyloxy)-5-nitrobenzyl iodide 

Relevant academic research and scientific papers

Convenient Assembly of Privileged (Hetero)Arene-Fused Benzo[1.4]oxazepines via Two Tandem SNAr Events. Part 1 – On the Importance of the Intermittent Smiles Rearrangement

New bis-nucleophilic precursors to [1.4]oxazepines synthesized via SNAr-Smiles rearrangement-SNAr cascade have been designed. Employing them in base-promoted condensation with aromatic bis-electrophiles allowed differentiating between highly and poorly reactive substrates (i.e. those which can and cannot pass through the Smiles rearrangement barrier, respectively). The reactivity toward the desired course of cyclization can be restored by introducing electron-withdrawing substituents in the bis-electrophile precursor. This strongly argues for the importance of the Smiles rearrangement for the successful overall ring formation.

A practical solution for aqueous reactions of water-insoluble high-melting-point organic substrates

A practical solution to the problem of performing aqueous reactions for very sparingly soluble high-melting-point (VSSHMP) organic substrates has been developed, which entails mechanically stirring a mixture of the substrate, the corresponding reagent(s), water, catalytic Aliquat 336 and sand. When the melting points of the substrates which include steroids, ketones, aldehydes, aromatics and alkaloids are around 200 °C, the reactions can be performed at 20 °C. The substrate solubility can be as low as 1 × 10-10 mol L-1. The Royal Society of Chemistry 2012.

Bicyclic compositions and methods for modulating a kinase cascade

The invention relates to compounds and methods for modulating one or more components of a kinase cascade.

Design of New Photoactivatable Amino Acids: Stereoselective Synthesis of N-Protected Phenylalanine Derivatives as Precursors of p-Diazocyclohexadienone-Containing Peptides

4-Diazocyclohexa-2,5-dienone-based amino acids m-Dip and o-Dip were designed for building up photoactivatable peptides.Their stable precursors L-3-alanine (L-m-Nip(Bn)) and L-3-alanine (L-o-Nip(Bn)