16874-81-0

Basic information

• Product Name: H-HIS-PHE-OH
• Synonyms: L-HISTIDYL-L-PHENYLALANINE;H-HIS-PHE-OH;his-phe;histidylphenylalanine
• CAS NO: 16874-81-0
• Molecular Formula: C₁₅H₁₈N₄O₃
• Molecular Weight: 302.33
• Product Categories: Amino Acid Derivatives;Dipeptides;Dipeptides and Tripeptides;Peptides
• Mol File: 16874-81-0.mol

Chemical Properties

• Melting Point: 255-258 °C (decomp)
• Boiling Point: 693.4 °C at 760 mmHg
• Flash Point: 373.1 °C
• Appearance: /
• Density: 1.34 g/cm³
• Vapor Pressure: 3.5E-20mmHg at 25°C
• Refractive Index: 1.627
• Storage Temp.: −20°C
• Solubility: Aqueous Acid (Slightly)
• PKA: 3.36±0.10(Predicted)
• CAS DataBase Reference: H-HIS-PHE-OH(CAS DataBase Reference)
• NIST Chemistry Reference: H-HIS-PHE-OH(16874-81-0)
• EPA Substance Registry System: H-HIS-PHE-OH(16874-81-0)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 16874-81-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Development:
H-HIS-PHE-OH is used as a potential therapeutic agent for [application reason], leveraging the combined properties of histidine and phenylalanine to target specific biological processes or conditions.
Used in Nutritional Supplements:
H-HIS-PHE-OH is used as a dietary supplement to provide essential amino acids for [application reason], such as enhancing immune function, supporting protein synthesis, or aiding in neurotransmitter production.
Used in Research:
H-HIS-PHE-OH is used as a research tool to study [application reason], including the exploration of the synergistic effects of histidine and phenylalanine in biological systems and their potential impact on health and disease.

InChI:InChI=1/C15H18N4O3/c16-12(7-11-8-17-9-18-11)14(20)19-13(15(21)22)6-10-4-2-1-3-5-10/h1-5,8-9,12-13H,6-7,16H2,(H,17,18)(H,19,20)(H,21,22)

Upstream product

• 4491-15-0 Z-His-Phe-OMe 
• 41445-69-6 N-benzyloxycarbonyl-L-histidyl azide 
• 2577-90-4 methyl (2S)-2-amino-3-phenylpropanoate 
• 63-91-2 L-phenylalanine 
• 13053-69-5 Z-L-His-L-Phe 

Downstream Products

• 122295-43-6 N²-benzyloxycarbonyl-L-glutaminyl=>L-histidyl=>L-phenylalanine 

Relevant articles and documents

Amino-acids and Peptides. Part 45. The Protection of the Thiol Function of Cysteine and the Imidazole-N of Histidine by the Diphenyl-4-pyridylmethyl Group

S-(Diphenyl-4-pyridylmethyl)-L-cysteine (1) and its derivatives (2)-(7) have been prepared and used in peptide synthesis.In contrast to the analogous S-trityl group, this protection is stable in acid but it is cleaved readily by zinc-acetic acid, by mercury(II) acetate, by iodine, and by electrolytic reduction.N(Im)-Diphenyl-4-pyridylmethyl-L-histidine derivatives (9)-(13) are also reported; the protecting group is again stable to acid but cleaved by hydrogenolysis, by zinc-acetic acid, and by electrolytic reduction, and it has been used in the synthesis of L-histidyl-L-leucine, -L-phenylalanine, and -glycine.