168772-58-5

Upstream product

• 65-71-4 thymin 
• 55559-64-3 (S)-1-(thymin-1-yl)-propane-2,3-diol 
• 55559-63-2 (S)-2,2-dimethyl-4-(thymin-1-ylmethyl)-1,3-dioxolane 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 870-24-6 2-chloroethanamine hydrochloride 
• 168332-12-5 (S)-1-<3-(4,4'-dimethoxytrityloxy)-2-hydroxypropyl>thymine 

Downstream Products

• 168772-59-6 (2S,3S,5R)-3-Hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-carboxylic acid {2-[(S)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-1-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl)-ethoxy]-ethyl}-amide 

Relevant academic research and scientific papers

Evaluation of oligonucleotides with novel modifications

Oligodeoxynucleotides modified with carboxamide linked dimeric nucleotides and an acyclic nucleoside were prepared and investigated for their hybridization properties toward DNA.

Synthesis of a carboxamide linked T*T dimer with an acyclic nucleoside unit and its incorporation in oligodeoxynucleotides

A T*T dimer with * representing a 2'-OCH2CH2NHC(O)-4' linkage connecting two nucleoside units was prepared by condensation of (S)-1-[2-(2- aminoethoxy)-3-(4,4'-dimethoxytrityloxy)propyl]thymine with 1,2-dideoxy-1- thyminyl-β-D-erythr