168332-12-5

Usage

Uses

Used in Research Applications:
(S)-1-<3-(4,4'-dimethoxytrityloxy)-2-hydroxypropyl>thymine is used as a building block for the synthesis of modified DNA and RNA sequences. Its unique structure and properties allow researchers to create custom-designed nucleic acids for various research purposes, such as studying gene function, understanding molecular interactions, and developing new diagnostic tools.
Used in Pharmaceutical Applications:
In the pharmaceutical industry, (S)-1-<3-(4,4'-dimethoxytrityloxy)-2-hydroxypropyl>thymine is used as a key component in the development of novel therapeutic agents. Its ability to form modified nucleic acids makes it a valuable asset in the creation of new drugs targeting specific genetic disorders or diseases at the molecular level.
Used in Drug Delivery Systems:
(S)-1-<3-(4,4'-dimethoxytrityloxy)-2-hydroxypropyl>thymine can also be employed in the development of drug delivery systems. Its unique structure allows for the creation of targeted drug delivery vehicles, potentially improving the efficacy and specificity of therapeutic agents in treating various diseases.
Overall, (S)-1-<3-(4,4'-dimethoxytrityloxy)-2-hydroxypropyl>thymine is a versatile compound with a wide range of applications in both research and pharmaceutical industries, making it an essential tool for advancing our understanding of molecular biology and developing new treatments for various diseases.

Upstream product

• 65-71-4 thymin 
• 55559-63-2 (S)-2,2-dimethyl-4-(thymin-1-ylmethyl)-1,3-dioxolane 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 834906-31-9 (S)-glycidyl 4,4’-dimethoxytrityl ether 
• 55559-64-3 (S)-1-(thymin-1-yl)-propane-2,3-diol 

Downstream Products

• 168772-58-5 (S)-1-<2-(2-aminoethoxy)-3-(4,4'-dimethoxytrityloxy)propyl>thymine 
• 168772-59-6 (2S,3S,5R)-3-Hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-carboxylic acid {2-[(S)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-1-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl)-ethoxy]-ethyl}-amide 

Relevant academic research and scientific papers

Synthesis of a carboxamide linked T*T dimer with an acyclic nucleoside unit and its incorporation in oligodeoxynucleotides

A T*T dimer with * representing a 2'-OCH2CH2NHC(O)-4' linkage connecting two nucleoside units was prepared by condensation of (S)-1-[2-(2- aminoethoxy)-3-(4,4'-dimethoxytrityloxy)propyl]thymine with 1,2-dideoxy-1- thyminyl-β-D-erythr

P-Stereodefined phosphorothioate analogs of glycol nucleic acids—synthesis and structural properties

Enantiomerically pure, protected acyclic nucleosides of the GNA type (glycol nucleic acids) (GN′), obtained from (R)-(+)- and (S)-(?)-glycidols and the four canonical DNA nucleobases (Ade, Cyt, Gua and Thy), were transformed into 3′-O-DMT-prote

Chirality Dependent Potency Enhancement and Structural Impact of Glycol Nucleic Acid Modification on siRNA

Here we report the investigation of glycol nucleic acid (GNA), an acyclic nucleic acid analogue, as a modification of siRNA duplexes. We evaluated the impact of (S)- or (R)-GNA nucleotide incorporation on RNA duplex structure by determining three individu

Synthesis of glycol nucleic acids

Starting from glycidol, the synthesis of dimethoxytritylated glycol nucleoside phosphoramidites of adenine (A), thymine (T), uracil (U), guanine (G), and cytosine (C) is reported. These phosphoramidites are the building blocks for the automated solid phas

Glycerol nucleoside triphosphates: Synthesis and polymerase substrate activities

The synthesis of (S)-glycerol nucleoside triphosphates (gNTPs) and the analysis of their substrate activities for enzymatic polymerization is described. NTPs with simplified carbohydrate backbones such as the tNTPs (α-L-threose-NTPs) are polymerase substr

A simple glycol nucleic acid

A glycol nucleic acid (GNA) with an acyclic propylene glycol phosphodiester backbone forms stable antiparallel duplexes following the Watson-Crick base pairing rules. Copyright

Synthesis of propane-2,3-diol combinatorial monomers

Base catalyzed reaction of heterocyclic bases with R-(+)-glycidol gives heteroaryl-propane-2,3-diols which are functionalized to the 3-O-dimethoxytrityl-2-O-phosphoramidites. A dimethoxytrityl-glycidol is reacted with alkyl or aryl Grignard reagents and then phosphitylated to yield 1-O-dimethoxytrityl-2-phosphoramidites. These compounds can be used for combinatorial oligomer synthesis.

Evaluation of oligonucleotides with novel modifications

Oligodeoxynucleotides modified with carboxamide linked dimeric nucleotides and an acyclic nucleoside were prepared and investigated for their hybridization properties toward DNA.