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Usage

Uses

Used in Pharmaceutical Industry:
Sodium 4-pyridinecarboxylate tetrahydrate is used as a raw material for the production of various drugs, contributing to the development of new medicinal compounds.
Used in Food Industry:
In the food industry, it is used as a leavening agent, helping to improve the texture and quality of food products.
Used in Textile Industry:
Sodium 4-pyridinecarboxylate tetrahydrate is used as a stabilizer, enhancing the durability and performance of textiles.
Used in Metal Manufacturing:
In the manufacturing of metal products, it serves as a corrosion inhibitor, protecting metal surfaces from degradation and wear.
Used in Analytical Chemistry:
It is utilized as a chelating agent, which helps in the separation and purification of various chemical compounds.
Used in Biochemical and Biological Research:
Sodium 4-pyridinecarboxylate tetrahydrate is used as a pH buffer, maintaining stable pH levels in experiments and research, which is crucial for accurate results and analysis.

InChI:InChI=1/C6H5NO2.Na/c8-6(9)5-1-3-7-4-2-5;/h1-4H,(H,8,9);/q;+1/p-1

Upstream product

• 178809-75-1 4-(1-hydroxy-1-(4-pyridyl)methyl)-1-nitrobenzene 
• 1083-48-3 4-Nitrobenzylpyridin 
• 39055-88-4 (4-nitrophenyl)(pyridin-4-yl)methanone 
• 4427-22-9 4-pyridinecarbohydroxamic acid 
• 55-22-1 pyridine-4-carboxylic acid 

Downstream Products

• 876522-62-2 N-(2-(tert-butylcarbamoyl)phenyl)isonicotinamide 
• 72121-34-7 1,2-ethanediyl di-4-pyridine carboxylate 
• 523999-81-7 [Rh₂(N,N'-di-p-tolylformamidinate)2(isonicotinate)2] 
• 70359-29-4 bromure de pyridine-4 carbonyloxy-3 propyltriphenylphosphonium 

Relevant academic research and scientific papers

Mn(II), Fe(II), Co(II), Ni(II), Cu(II) and Zn(II) transition metals isonicotinate complexes: Thermal behavior in N2 and air atmospheres and spectroscopic characterization

Solid-state M(IN)2·nH2O complexes, where M stands for bivalent transition metals (Mn, Fe, Co, Ni, Cu and Zn), IN is isonicotinate and n = 0.5 to 4.0 H2O, were synthesized. Characterization and thermal behavior of the compounds were performed employing elemental analysis (EA), complexometric titration with EDTA, powder X-ray diffraction (PXRD), infrared spectroscopy (FTIR), simultaneous thermogravimetry and differential scanning calorimetry (TG–DSC) in dynamic dry air and nitrogen atmospheres, differential scanning calorimetry (DSC) and TG–DSC coupled to FTIR. The thermal behavior of isonicotinic acid and its sodium salt was also investigated in both atmospheres. The dehydration of these compounds occurs in a single step in both atmospheres. In air atmosphere, the thermal decomposition of the anhydrous compounds also occurs in a single step, except for the copper compound where two steps are observed. In N2 the thermal decomposition of the anhydrous compounds occurs in two consecutive steps, except for iron compound, where three steps are observed. The main gaseous products of thermal decomposition/pyrolysis of the compounds were identified as CO, CO2 and Pyridine. Mn, Co, Cu and Zn compounds show a physical transformation process in DSC curves. The ligand coordinates through the pyridine nitrogen atom to the metal and for the Zn compound, the carboxylate group also participates in the coordination. The IR absorption profile of hydrated and dehydrated compounds suggest that there is a probable change in the coordination mode of the ligand upon dehydration. This change needs to be further investigated, once it is not possible to ensure only with infrared spectroscopy data.

Lanthanide complexes with pyridinecarboxylic acids – Spectroscopic and thermal studies

The effect of 14 lanthanides on the structure and the electronic system of isonicotinic acid was studied using IR (KBr), IR (ATR), Raman, UV–Vis, spectrofluorometric, elemental analysis and thermogravimetric (TG/DTG) methods. The influence of the lanthanides ions on the electronic charge distribution of the ligand is discussed. The nephelauxetic parameters and the degree of covalency in the lanthanide–ligand bonds were established. Moreover, the molecular structures of the lanthanide complexes with isonicotinic, nicotinic, picolinic and benzoic acids were compared, with a particular emphasis on the changes within the aromatic ring of metal complexes.

NMR and theoretical study on interactions between diperoxovanadate complex and 4-substituted pyridines

To understand the substituting group effects of organic ligands on the reaction equilibrium, the interactions between diperoxovanadate complex [OV(O2)2(D2O)]-/[OV(O 2)2(HOD)]- and a series of 4-substituted pyridines in solution were explored using multinuclear (1H, 13C, and 51V) magnetic resonance, DOSY, and variable temperature NMR in 0.15 mol/L NaCl ionic medium for mimicking the physiological condition. Some direct NMR data are given for the first time. The reactivity among the 4-substituted pyridines is pyridine > isonicotinate > N-methyl isonicotinamide > methyl isonicotinate. The competitive coordination results in the formation of a series of new six-coordinated peroxovanadate species [OV(O2)2L]n- (L = 4-substituted pyridines, n = 1 or 2). The results of density functional calculations provide a reasonable explanation on the relative reactivity of the 4-substituted pyridines. Solvation effects play an important role in these reactions.

Mechanistic insights into the: In vitro metal-promoted oxidation of (di)azine hydroxamic acids: Evidence of HNO release and N, O -di(di)azinoyl hydroxylamine intermediate

The oxidant-dependent ability of hydroxamic acids to release nitroxyl (HNO), a small inorganic molecule endowed with various biological properties, is addressed from a mechanistic standpoint. Indeed, the exact mechanism of the hydroxamic acid oxidation in physiological conditions and the direct or indirect characterization of the intermediates remain elusive. In this work, intermolecular oxidation of isonicotino-, nicotino- and pyrazino-hydroxamic acids with K3[FeIII(CN)6] at physiological pH (7.4), was monitored by 1H NMR, MS, EPR and UV-vis techniques. While nitrosocarbonyl (di)azine intermediates, (di)Az-C(O)-NO, could be a priori envisaged, it was in fact the corresponding N,O-di(di)azinoylhydroxylamines (AzC(O)NHOC(O)Az) and HNO that were identified, the first by 1H NMR and the second on the basis of EPR and UV-vis experiments using the [2-(4-carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide] (cPTIO) spin trap. The decomposition of the unstable N,O-di(di)azinoylhydroxylamine intermediates in aqueous buffer media was shown to generate the corresponding carboxylic acids as final organic products, envisaged as possible in vivo metabolites. The same oxidation experiments performed in the presence of methylamine led to the corresponding N-methyl amides suggesting that, unlike hydroxamic acids, N,O-di(di)azinoylhydroxylamines act as acylating agents in physiological pH conditions.

Hydroxide-promoted redox reactions in water of α-phenyl-4-nitrobenzenemethanol, α-(p-nitrophenyl)-4-pyridinemethanol, and α-(p-Nitrophenyl)-4-pyridinemethanol N-oxide steric inhibition of resonance

α-Phenyl-4-nitrobenzenemethanol (3) reacted with 1 M sodium hydroxide to yield 4,4′-dibenzoylazoybenzene (5) (51%), 4-hydroxy-4′-benzoylazobenzene (6) and benzoic acid (12% each), and smaller amounts of 4-aminobenzophenone and 4-nitrobenzophenone. Both α-phenyl-2-nitrobenzenemethanol (9) and 3,5-dimethyl-4-nitrobenzenemethanol (10a) did not react with 1 M sodium hydroxide, presumably due to steric hindrance. α-(p-Nitrophenyl)-4-pyridinemethanol (14) and its N-oxide 11 with 1 M sodium hydroxide yielded 4,4′-diaroylazoxybenzenes 15a and 12a, respectively, 4,4′-diaroylazobenzenes 15b and 12b, respectively, as well as 4-hydroxy-4′-aroylazobenzenes 16 and 13, respectively. The relative reaction rates were 11 > 14 > 3. Studies with 11 showed that the nitro group is involved in the redox reaction in preference to the N-oxide group.