1083-48-3Relevant academic research and scientific papers
HYDANTOIN DERIVATIVE
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Paragraph 0616, (2021/03/13)
A compound represented by general formula (I-a) : has a strong DDR1 inhibitory activity, and can be a therapeutic agent for DDR1-related diseases, for example, a cancer, a kidney disease, a cardiovascular disease, a central nervous system disease, or fibrosis.
Efficient Selenium-Catalyzed Selective C(sp3)?H Oxidation of Benzylpyridines with Molecular Oxygen
Jin, Weiwei,Zheng, Poonnapa,Wong, Wing-Tak,Law, Ga-Lai
supporting information, p. 1588 - 1593 (2017/05/05)
An efficient selenium-catalyzed direct oxidation of benzylpyridines in aqueous DMSO has been successfully developed by using molecular oxygen as the oxidant. A variety of benzoylpyridines with broad functional group tolerance were obtained in modest to excellent yields and with exclusive chemoselectivity. (Figure presented.).
Vicarious nucleophilic substitution of (chloroalkyl)heterocycles with nitroarenes
Florio, Saverio,Lorusso, Patrizia,Luisi, Renzo,Granito, Catia,Ronzini, Ludovico,Troisi, Luigino
, p. 2118 - 2124 (2007/10/03)
The vicarious nucleophilic substitution of potassium carbanions of the (chloromethyl)pyridines 1a and 1b, (chloromethyl)benzothiazole 1c, (chloromethyl)thiazole 1d, (chloroethyl)thiazole 1e and (chloroethyl) benzothiazole 1f wit nitroarenes, leading to ni
Tuning the redox chemistry of 4-benzoyl-N-methylpyridinium cations through para substitution. Hammett linear free energy relationships and the relative aptitude of the two-electron reduced forms for H-bonding
Leventis, Nicholas,Rawaswdeh, Abdel-Monem M.,Zhang, Guohui,Elder, Ian A.,Sotiriou-Leventis, Chariklia
, p. 7501 - 7510 (2007/10/03)
In anhydrous CH3CN a series of nine 4-(4-substituted-benzoyl)-N-methylpyridinium cations (substituent: -OCH3, -CH3, -H, -SCH3, -Br, -C≡CH, -CHO, -NO2, and -+S(CH3)2) demonstrate two chemically reversible, well-separated one-electron (1-e) reductions in the same potential range as other main stream redox catalysts such as quinones and viologens. Hammett linear free energy plots yield excellent correlation between the E1/2 values of both waves and the substituent constants σp-X. The reaction constants for the two 1-e reductions are ρ1 = 2.60 and ρ2 = 3.31. The lower ρ1 value is associated with neutralization of the pyridinium ring, and the higher ρ2 value with the negative charge developing during the 2nd-e reduction. Structure-function correlations point to a purely inductive role for substitution in both 1-e reductions. The case of the 4-(4-nitrobenzoyl)-N-methylpyridinium cation is particularly noteworthy, because the 4-nitrobenzoyl moiety undergoes reduction before the 2nd reduction of the 4-benzoyl-N-methylpyridinium system. Correlation of the third wave of this compound with the 2nd-e reduction of the others yields σp-NO2- = -0.97 ± 0.02, thus placing the -NO2- group among the strongest electron donors. Solvent deuterium isotope effects and maps of the electrostatic potential (via PM3 calculations) as a function of substitution support that 2-e reduced forms develop H-bonding with proton donors (e.g., CH3-OH) via the O-atom. The average number of CH3OH molecules entering the H-bonding association increases with e-donating substituents. H-bonding shifts the 2nd reduction wave closer to the first one. This has important practical implications, because it increases the equilibrium concentration of the 2-e reduced form from disproportionation of the 1-e reduced form.
