168907-66-2

Basic information

• Product Name: 1-Butanone, 1-(4-bromophenyl)-4-iodo-
• CAS NO: 168907-66-2
• Molecular Formula: C10H10BrIO
• Molecular Weight: 352.997
• Mol File: 168907-66-2.mol

Chemical Properties

• CAS DataBase Reference: 1-Butanone, 1-(4-bromophenyl)-4-iodo-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Butanone, 1-(4-bromophenyl)-4-iodo-(168907-66-2)
• EPA Substance Registry System: 1-Butanone, 1-(4-bromophenyl)-4-iodo-(168907-66-2)

Safety Data

• Hazardous Substances Data: 168907-66-2(Hazardous Substances Data)

Upstream product

• 4559-96-0 1-(4-bromophenyl)-4-chlorobutan-1-one 
• 16029-98-4 trimethylsilyl iodide 
• 6952-89-2 (4-bromophenyl)(cyclopropyl)methanone 
• 1250239-87-2 1-(4-bromophenyl)-4-hydroxybutan-1-one 
• 106-37-6 1.4-dibromobenzene 

Downstream Products

• 43076-33-1 1-(4-bromophenyl)-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butan-1-one 
• 97928-45-5 4-diphenylmethoxy-1-[3-(4-bromobenzoyl)propyl]-piperidine 
• 168907-70-8 2-{3-[2-(4-Bromo-phenyl)-[1,3]dioxolan-2-yl]-propyl}-1-methyl-1H-imidazole 
• 168907-74-2 1-(4-bromophenyl)-4-(1-methyl-2-imidazolyl)-1-butanone 
• 168907-68-4 2-(4-bromophenyl)-2-(3-iodopropyl)-1,3-dioxolane 

Relevant articles and documents

Catalytic asymmetric intramolecular homologation of ketones with α-diazoesters: Synthesis of cyclic α-Aryl/Alkyl β-ketoesters

A catalytic asymmetric intramolecular homologation of simple ketones with α-diazoesters was firstly accomplished with a chiral N,N′-dioxide-Sc(OTf)3 complex. This method provides an efficient access to chiral cyclic α-aryl/alkyl β-ketoesters containing an all-carbon quaternary stereocenter. Under mild conditions, a variety of aryl- and alkyl-substituted ketone groups reacted with α-diazoester groups smoothly through an intramolecular addition/rearrangement process, producing the β-ketoesters in high yield and enantiomeric excess.

Process for production of piperidine derivatives

Processes are disclosed for preparing piperidine derivative compounds of the formulae I, II or III: The processes involve reacting a compound of formula Ia, IIa or IIIa with isobutyrate or an isobutyrate equivalent.

Process for production of carebastine

Processes are disclosed for preparing piperidine derivative compounds of the formulae I, II or III:

Synthesis of Aryl 3-(2-Imidazolyl)propyl Ketones.

The approach to the title compounds was via lithiation-substitution of N-methyl or N-(triphenylmethyl)imidazole by some iodo ketals. 4-Chloro-4'-halobutyrophenones (halo = F, Cl, Br) were converted by sodium iodide to the corresponding aliphatic iodides which were subsequently ketalized with ethylene glycol to provide the corresponding iodo ketals.Lithiation of either 1-methyl- or 1-(triphenylmethyl)imidazole with n-butyllithium generated the corresponding 2-lithioimidazoles, in situ, which were then reacted with these iodo ketals to form the corresponding C-2 substitute d imidazoles.Dilute aqueous acid hydrolysis released the ketone from the ketal.For N-triphenylmethyl protected imidazoles, the triphenylmethyl group was also hydrolyzed to give triphenylmethanol and 3-(2-imidazolyl)propyl 4-haloaryl ketones.These N-unsubstituted imidazolyl ketones can be alkylated independently with triphenylmethyl chloride to form the corresponding N-triphenylmethyl imidazole derivatives.