168907-71-9

Basic information

• Product Name: 2-{3-[2-(4-Fluoro-phenyl)-[1,3]dioxolan-2-yl]-propyl}-1-methyl-1H-imidazole
• Synonyms: 2-{3-[2-(4-Fluoro-phenyl)-[1,3]dioxolan-2-yl]-propyl}-1-methyl-1H-imidazole
• CAS NO: 168907-71-9
• Molecular Weight: 290.337
• Mol File: 168907-71-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-{3-[2-(4-Fluoro-phenyl)-[1,3]dioxolan-2-yl]-propyl}-1-methyl-1H-imidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-{3-[2-(4-Fluoro-phenyl)-[1,3]dioxolan-2-yl]-propyl}-1-methyl-1H-imidazole(168907-71-9)
• EPA Substance Registry System: 2-{3-[2-(4-Fluoro-phenyl)-[1,3]dioxolan-2-yl]-propyl}-1-methyl-1H-imidazole(168907-71-9)

Safety Data

• Hazardous Substances Data: 168907-71-9(Hazardous Substances Data)

Upstream product

• 616-47-7 1-methyl-1H-imidazole 
• 62746-77-4 2-(4-fluorophenyl)-2-(3-iodopropyl)-1,3-dioxolane 
• 3874-54-2 4-(4-fluorophenyl)-4-oxo-n-butyl chloride 
• 40862-32-6 1-iodo-3-(p-fluorophenylcarbonyl)propane 

Downstream Products

• 168907-75-3 1-(4-fluorophenyl)-4-(1-methyl-2-imidazolyl)-1-butanone 

Relevant articles and documents

Synthesis of Aryl 3-(2-Imidazolyl)propyl Ketones.

The approach to the title compounds was via lithiation-substitution of N-methyl or N-(triphenylmethyl)imidazole by some iodo ketals. 4-Chloro-4'-halobutyrophenones (halo = F, Cl, Br) were converted by sodium iodide to the corresponding aliphatic iodides which were subsequently ketalized with ethylene glycol to provide the corresponding iodo ketals.Lithiation of either 1-methyl- or 1-(triphenylmethyl)imidazole with n-butyllithium generated the corresponding 2-lithioimidazoles, in situ, which were then reacted with these iodo ketals to form the corresponding C-2 substitute d imidazoles.Dilute aqueous acid hydrolysis released the ketone from the ketal.For N-triphenylmethyl protected imidazoles, the triphenylmethyl group was also hydrolyzed to give triphenylmethanol and 3-(2-imidazolyl)propyl 4-haloaryl ketones.These N-unsubstituted imidazolyl ketones can be alkylated independently with triphenylmethyl chloride to form the corresponding N-triphenylmethyl imidazole derivatives.