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Usage

Uses

Used in Pharmaceutical Industry:
Benzenesulfonamide, 4-(methylamino)(9CI) is used as a chemical intermediate for the synthesis of various drugs, particularly those with antimicrobial and antibacterial properties. Its unique structure allows it to be a key component in the development of new medications that can combat resistant strains of bacteria and other microorganisms.
Used in Dye and Pigment Production:
In addition to its pharmaceutical applications, Benzenesulfonamide, 4-(methylamino)(9CI) is also utilized in the production of dyes and pigments. Its chemical properties make it suitable for creating a wide range of colors and shades, which can be used in various industries such as textiles, plastics, and printing inks.
Environmental Considerations:

Upstream product

• 39169-92-1 4-(N-acetyl-N-methylamino)benzenesulfonyl chloride 
• 67-56-1 methanol 
• 63-74-1 sulfanilamide 
• 56209-08-6 p-(N-acetyl-N-methylamino)benzenesulfonamide 
• 579-10-2 N-acetyl-N-methylaniline 

Downstream Products

• 134907-20-3 4-{N-methyl-N-[(E)-3-(3,4-dihydroxyphenyl)-2-propenoyl]amino}benzenesulfonamide 
• 126826-54-8 N-[1-Ethyl-pyrrolidin-(2Z)-ylidene]-4-methylamino-benzenesulfonamide 

Relevant academic research and scientific papers

Palladacycle-Phosphine Catalyzed Methylation of Amines and Ketones Using Methanol

Methylation of amines and ketones with palladacycle precatalyst has been performed using methanol as an environmentally benign reagent. Various ketones and amines undergo methylation reaction to yield monomethylated amines or ketones in moderate to good isolated yields. Moreover, this protocol was tested for the chemoselective methylation of 4-aminobenzenesulfonamide. The scope of the reaction was further extended to the deuteromethylation of ketones.

(1-(4-(Naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-yl)methanamine: A wingless β-catenin agonist that increases bone formation rate

A high-throughput screening campaign to discover small molecule leads for the treatment of bone disorders concluded with the discovery of a compound with a 2-aminopyrimidine template that targeted the Wnt β-catenin cellular messaging system. Hit-tolead in

PYRIMIDINE SULFONAMIDE ANALOGS AND THEIR USE AS AGONISTS OF THE WNT-BETA-CATENIN CELLULAR MESSAGING SYSTEM

The present invention relates to pyrimidine sulfonamide analogs, methods of making pyrimidine sulfonamide analogs, compositions comprising a pyrimidine sulfonamide analog, and methods for treating canonical Wnt-β-catenin cellular messaging system-related disorders comprising administering to a subject in need thereof an effective amount of a pyrimidine sulfonamide analog.

Synthesis and biological evaluation of substituted benzenesulfonamides as novel potent membrane-bound phospholipase A2 inhibitors

A novel series of 4-[N-methyl-N-[(E)-3-[4-(methylsulfonyl)phenyl]-2-propenoyl]amino]benz enesulfonamides has been prepared and evaluated as membrane-bound phospholipase A2 inhibitors. A structure-activity relationship study indicated that the o